| Gene Symbol |
TMPRSS6
|
| Entrez Gene |
164656
|
| Alt Symbol |
IRIDA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transmembrane protease, serine 6
|
| Other Description |
matriptase-2|membrane-bound mosaic serine proteinase matriptase-2|transmembrane protease serine 6|type II transmembrane serine protease 6
|
| Swissprots |
Q8IUE2 Q6UXD8 Q6ICC2 B0QYB4 B0QYB7 B0QYB8 Q8IU80 Q8IXV8 Q5TI06
|
| Accessions |
AAL16413 EAW60141 EAW60142 EAW60143 Q8IU80 AJ319876 CAC85953 AW295507 AY055384 AAL16414 AY358398 AAQ88764 BC039082 AAH39082 CR456446 CAG30332 CU013044 CAK54475 CU013332 CAK54774 XM_006724162 XP_006724225 XM_006724163 XP_006724226 XM_011529987 XP_011528289 XM_011529988 XP_011528290 XM_011529989 XP_011528291 NM_001289000 NP_001275929 NM_001289001 NP_001275930 NM_153609 NP_705837
|
| Function |
Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Required to sense iron deficiency and suppress activation of the HAMP promoter. {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:18408718}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:20518742}; Single-pass type II membrane protein {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:20518742}.
|
| Tissue Specificity |
Liver specific. {ECO:0000269|PubMed:12149247}.
|
![Western Blot: Matriptase 2 Overexpression Lysate (Adult Normal) [NBP2-05248] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Matriptase 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5947_Matriptase%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05248-img0001.jpg)