TMPRSS6

Gene Symbol TMPRSS6
Entrez Gene 164656
Alt Symbol IRIDA
Species Human
Gene Type protein-coding
Description transmembrane protease, serine 6
Other Description matriptase-2|membrane-bound mosaic serine proteinase matriptase-2|transmembrane protease serine 6|type II transmembrane serine protease 6
Swissprots Q8IUE2 Q6UXD8 Q6ICC2 B0QYB4 B0QYB7 B0QYB8 Q8IU80 Q8IXV8 Q5TI06
Accessions AAL16413 EAW60141 EAW60142 EAW60143 Q8IU80 AJ319876 CAC85953 AW295507 AY055384 AAL16414 AY358398 AAQ88764 BC039082 AAH39082 CR456446 CAG30332 CU013044 CAK54475 CU013332 CAK54774 XM_006724162 XP_006724225 XM_006724163 XP_006724226 XM_011529987 XP_011528289 XM_011529988 XP_011528290 XM_011529989 XP_011528291 NM_001289000 NP_001275929 NM_001289001 NP_001275930 NM_153609 NP_705837
Function Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Required to sense iron deficiency and suppress activation of the HAMP promoter. {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:18408718}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:20518742}; Single-pass type II membrane protein {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:20518742}.
Tissue Specificity Liver specific. {ECO:0000269|PubMed:12149247}.

Matriptase-2 (H-300) - sc-366194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Matriptase-2 (H-300): sc-366194. Western blot analysis of Matriptase-2 expression in non-transfected 293T: sc-117752 (A), human Matriptase-2 transfected 293T: sc-114572 (B) and Hep G2 (C) whole cell lysates and mouse liver (D) and rat liver (E) tissue extracts.

Matriptase-2 (S-20) - sc-54240 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Matriptase-2 (S-20): sc-54240. Western blot analysis of Matriptase-2 expression in MCF7 whole cell lysate.

Anti-Matriptase 2 antibody - ab28287 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab28287 stained Hek293 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28287, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Matriptase 2 antibody - ab59782 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Matriptase 2 antibody (ab59782) at 1/1000 dilutionLane 1 : Cell media from human embryonic kidney HEK293 cells (treated with SF) Lane 2 : Cell media from human embryonic kidney HEK293 cells (treated with TPA) Lane 3 : Cell media from human embryonic kidney HEK293 cells (treated with ILA-1 alpha) Lysates/proteins at 20 µl per lane.

Anti-Matriptase 2 antibody - ab106842 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Matriptase 2 antibody (ab106842) at 1 µg/ml + Jurkat cell lysate at 10 µg

Anti-Matriptase 2 antibody - Catalytic domain - ab59783 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Matriptase 2 antibody - Catalytic domain (ab59783) at 1/1000 dilutionLane 1 : SK-HEP-1 CM sfLane 2 : SK-HEP-1 TPALane 3 : SK-HEP-1 IL-1bLane 4 : SK-HEP-1 TNFaLane 5 : SK-HEP-1 RA

Anti-Matriptase 2 antibody - Catalytic domain - ab56182 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Matriptase 2 antibody - Catalytic domain (ab56182) at 1/1000 dilutionLane 1 : Cell media from human amnion-derived WISH cellsLane 2 : Cell media from human amnion-derived WISH cells

Anti-Matriptase 2 antibody - CUB-2 domain - ab56181 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Matriptase 2 antibody - CUB-2 domain (ab56181) at 1/1000 dilutionLane 1 : Cell media from human embryonic kidney HEK293 cellsLane 2 : Cell media from human embryonic kidney HEK293 cellsLane 3 : Cell media from human embryonic kidney HEK293 cells

Anti-Matriptase 2 antibody - Cytoplasmic domain - ab56180 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Matriptase 2 antibody - Cytoplasmic domain (ab56180) at 1/1000 dilutionLane 1 : Cell media from human embryonic kidney HEK293 cellsLane 2 : Cell media from human embryonic kidney HEK293 cellsLane 3 : Cell media from human embryonic kidney HEK293 cells

Anti-Matriptase 2 antibody - Cytoplasmic domain - ab28286 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab28286 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28286, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TMPRSS6 Antibody (aa71-120) IHC-plus™ - LS-B5835 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TMPRSS6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5835 concentration 5 ug/ml.

Anti-TMPRSS6 Antibody (aa85-114, AP) - LS-C241922 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa85-114, APC) - LS-C241924 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa85-114, Biotin) - LS-C241925 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa85-114, FITC) - LS-C241926 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa85-114, PE) - LS-C241930 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa85-114, Azide-free, HRP) - LS-C247091 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa84-114) - LS-C325822 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 Antibody (aa85-114) - LS-C156245 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TMPRSS6 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The TMPRSS6 antibody detected the TMPRSS6 protein (arrow).

Matriptase 2 Antibody - NBP1-57098 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Matriptase 2 Antibody [NBP1-57098] - Titration: 0.2-1 ug/ml, Positive Control: Jurkat cell lysate.

Matriptase 2 Antibody - H00164656-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Matriptase 2 Antibody [H00164656-B01P] - Expression in transfected 293T cell line. Lane 1: TMPRSS6 transfected lysate(50.71 KDa). Lane 2: Non-transfected lysate.

Matriptase 2 Polyclonal Antibody - bs-8296R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS6 antibody produced in mouse - SAB1408403 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TMPRSS6: <B>Cat. No. SAB1408403</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~50.7 kDa using TMPRSS6 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-TMPRSS6, (N-terminal) antibody produced in rabbit - SAB2103628 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TMPRSS6, (N-terminal): <B>Cat. No. SAB2103628</B>: Immunohistochemistry of TMPRSS6 in Liver tissue with TMPRSS6 antibody at 5.0 μg/mL.

TMPRSS6 antibody - N-terminal region (ARP53188_P050) - ARP53188_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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