| Gene Symbol |
EDA2R
|
| Entrez Gene |
60401
|
| Alt Symbol |
EDA-A2R, EDAA2R, TNFRSF27, XEDAR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ectodysplasin A2 receptor
|
| Other Description |
EDA-A2 receptor|X-linked ectodysplasin-A2 receptor|tumor necrosis factor receptor superfamily member 27|tumor necrosis factor receptor superfamily member XEDAR
|
| Swissprots |
Q8IZA6 Q5VYY0 Q9HAV5 Q5VYX9 Q6UWM2
|
| Accessions |
EAX05382 Q9HAV5 AF298812 AAG28761 AK296264 BAG58977 AK299018 BAG61098 AK314881 BAG37396 AY152724 AAN73210 AY358735 AAQ89952 AY358736 AAQ89953 BC034919 AAH34919 BP249106 DA215848 DC368837 HQ447632 ADQ32117 XM_005262285 XP_005262342 XM_006724675 XP_006724738 XM_011531000 XP_011529302 XM_011531001 XP_011529303 XM_011531002 XP_011529304 XM_011531003 XP_011529305 XM_011531004 XP_011529306 XM_011531005 XP_011529307 XM_011531006 XP_011529308 XM_011531007 XP_011529309 XR_244499 XR_938404 XR_938405 XR_938406 NM_001199687 NP_001186616 NM_001242310 NP_001229239 NM_021783 NP_068555 NM_001199688 NM_001199689
|
| Function |
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}.
|
| Subcellular Location |
Membrane; Single-pass type III membrane protein.
|
| Top Pathways |
Cytokine-cytokine receptor interaction
|
