Gene Symbol | EDA2R |
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Entrez Gene | 60401 |
Alt Symbol | EDA-A2R, EDAA2R, TNFRSF27, XEDAR |
Species | Human |
Gene Type | protein-coding |
Description | ectodysplasin A2 receptor |
Other Description | EDA-A2 receptor|X-linked ectodysplasin-A2 receptor|tumor necrosis factor receptor superfamily member 27|tumor necrosis factor receptor superfamily member XEDAR |
Swissprots | Q8IZA6 Q5VYY0 Q9HAV5 Q5VYX9 Q6UWM2 |
Accessions | EAX05382 Q9HAV5 AF298812 AAG28761 AK296264 BAG58977 AK299018 BAG61098 AK314881 BAG37396 AY152724 AAN73210 AY358735 AAQ89952 AY358736 AAQ89953 BC034919 AAH34919 BP249106 DA215848 DC368837 HQ447632 ADQ32117 XM_005262285 XP_005262342 XM_006724675 XP_006724738 XM_011531000 XP_011529302 XM_011531001 XP_011529303 XM_011531002 XP_011529304 XM_011531003 XP_011529305 XM_011531004 XP_011529306 XM_011531005 XP_011529307 XM_011531006 XP_011529308 XM_011531007 XP_011529309 XR_244499 XR_938404 XR_938405 XR_938406 NM_001199687 NP_001186616 NM_001242310 NP_001229239 NM_021783 NP_068555 NM_001199688 NM_001199689 |
Function | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}. |
Subcellular Location | Membrane; Single-pass type III membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction |
XEDAR CRISPR/Cas9 KO Plasmid (h) - sc-417634 from Santa Cruz Biotechnology
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XEDAR HDR Plasmid (h) - sc-417634-HDR from Santa Cruz Biotechnology
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XEDAR Double Nickase Plasmid (h) - sc-417634-NIC from Santa Cruz Biotechnology
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XEDAR Double Nickase Plasmid (h2) - sc-417634-NIC-2 from Santa Cruz Biotechnology
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XEDAR CRISPR Activation Plasmid (h) - sc-417634-ACT from Santa Cruz Biotechnology
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XEDAR CRISPR Activation Plasmid (h2) - sc-417634-ACT-2 from Santa Cruz Biotechnology
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XEDAR Lentiviral Activation Particles (h) - sc-417634-LAC from Santa Cruz Biotechnology
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XEDAR Lentiviral Activation Particles (h2) - sc-417634-LAC-2 from Santa Cruz Biotechnology
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XEDAR siRNA (h) - sc-40249 from Santa Cruz Biotechnology
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XEDAR shRNA Plasmid (h) - sc-40249-SH from Santa Cruz Biotechnology
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XEDAR shRNA (h) Lentiviral Particles - sc-40249-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU099201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7644 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7644 from Sigma-Aldrich
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EDA2R siRNA (Human) - CRJ1791 from Cohesion Biosciences
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EDA2R/TNFRSF27/XEDAR RNAi - H00060401-R02 from Novus Biologicals
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EDA2R - MBS8209773 from MyBioSource
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shRNA set against Human EDA2R (NM_021783.3) - SHH283049 from Creative biogene
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EDA2R shRNA Plasmid (Human) - CHJ1791 from Cohesion Biosciences
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EDA2R miRNA 3'UTR clone - MiUTR4H-TG02952 from Creative biogene
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