| Gene Symbol |
PCDH12
|
| Entrez Gene |
51294
|
| Alt Symbol |
VE-cadherin-2, VECAD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protocadherin 12
|
| Other Description |
VE-cad-2|VE-cadherin 2|protocadherin-12|vascular cadherin-2|vascular endothelial cadherin 2|vascular endothelial cadherin-2
|
| Swissprots |
Q9H8E0 Q9H7Y6 Q96KB8 Q6UXB6 Q9NPG4
|
| Accessions |
EAW61898 Q9NPG4 AB026893 BAA95162 AF231025 AAF61931 AF240635 AAF73962 AK023785 BAB14677 AK024140 BAB14837 AK027282 BAB55016 AK226049 AK315029 BAG37515 AY358428 AAQ88794 BC042634 AAH42634 BC052973 AAH52973 CA418447 NM_016580 NP_057664
|
| Function |
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cell junction.
|
| Tissue Specificity |
Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen.
|
![Western Blot: Protocadherin 12 Overexpression Lysate (Adult Normal) [NBP2-07016] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Protocadherin 12.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8347_Protocadherin%252012%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07016-img0001.jpg)