Gene Symbol | PCDH12 |
---|---|
Entrez Gene | 51294 |
Alt Symbol | VE-cadherin-2, VECAD2 |
Species | Human |
Gene Type | protein-coding |
Description | protocadherin 12 |
Other Description | VE-cad-2|VE-cadherin 2|protocadherin-12|vascular cadherin-2|vascular endothelial cadherin 2|vascular endothelial cadherin-2 |
Swissprots | Q9H8E0 Q9H7Y6 Q96KB8 Q6UXB6 Q9NPG4 |
Accessions | EAW61898 Q9NPG4 AB026893 BAA95162 AF231025 AAF61931 AF240635 AAF73962 AK023785 BAB14677 AK024140 BAB14837 AK027282 BAB55016 AK226049 AK315029 BAG37515 AY358428 AAQ88794 BC042634 AAH42634 BC052973 AAH52973 CA418447 NM_016580 NP_057664 |
Function | Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction. |
Tissue Specificity | Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen. |