Gene Symbol | PCDH12 |
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Entrez Gene | 51294 |
Alt Symbol | VE-cadherin-2, VECAD2 |
Species | Human |
Gene Type | protein-coding |
Description | protocadherin 12 |
Other Description | VE-cad-2|VE-cadherin 2|protocadherin-12|vascular cadherin-2|vascular endothelial cadherin 2|vascular endothelial cadherin-2 |
Swissprots | Q9H8E0 Q9H7Y6 Q96KB8 Q6UXB6 Q9NPG4 |
Accessions | EAW61898 Q9NPG4 AB026893 BAA95162 AF231025 AAF61931 AF240635 AAF73962 AK023785 BAB14677 AK024140 BAB14837 AK027282 BAB55016 AK226049 AK315029 BAG37515 AY358428 AAQ88794 BC042634 AAH42634 BC052973 AAH52973 CA418447 NM_016580 NP_057664 |
Function | Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction. |
Tissue Specificity | Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen. |
VE-cadherin-2 CRISPR/Cas9 KO Plasmid (h) - sc-401695 from Santa Cruz Biotechnology
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VE-cadherin-2 HDR Plasmid (h) - sc-401695-HDR from Santa Cruz Biotechnology
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VE-cadherin-2 Double Nickase Plasmid (h) - sc-401695-NIC from Santa Cruz Biotechnology
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VE-cadherin-2 Double Nickase Plasmid (h2) - sc-401695-NIC-2 from Santa Cruz Biotechnology
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VE-cadherin-2 CRISPR Activation Plasmid (h) - sc-401695-ACT from Santa Cruz Biotechnology
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VE-cadherin-2 CRISPR Activation Plasmid (h2) - sc-401695-ACT-2 from Santa Cruz Biotechnology
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VE-cadherin-2 Lentiviral Activation Particles (h) - sc-401695-LAC from Santa Cruz Biotechnology
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VE-cadherin-2 Lentiviral Activation Particles (h2) - sc-401695-LAC-2 from Santa Cruz Biotechnology
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VE-cadherin-2 siRNA (h) - sc-76896 from Santa Cruz Biotechnology
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VE-cadherin-2 shRNA Plasmid (h) - sc-76896-SH from Santa Cruz Biotechnology
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VE-cadherin-2 shRNA (h) Lentiviral Particles - sc-76896-V from Santa Cruz Biotechnology
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Protocadherin-12 RNAi - H00051294-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16402 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16402 from Sigma-Aldrich
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PCDH12 siRNA (Human) - CRH9671 from Cohesion Biosciences
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VE-cadherin-2 CRISPR/Cas9 KO Plasmid (h2) - sc-401695-KO-2 from Santa Cruz Biotechnology
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VE-cadherin-2 HDR Plasmid (h2) - sc-401695-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PCDH12 (NM_016580.2) - SHH371456 from Creative biogene
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shRNA set against Human PCDH12(NM_016580.2) - SHR091524 from Creative biogene
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Human PCDH12 siRNA - orb270173 from Biorbyt
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PCDH12 shRNA Plasmid (Human) - CHH9671 from Cohesion Biosciences
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PCDH12 miRNA 3'UTR clone - MiUTR1H-07564 from Creative biogene
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