TNFRSF1B

Gene Symbol	TNFRSF1B
Entrez Gene	7133
Alt Symbol	CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 1B
Other Description	TNF-R2|TNF-RII|p75 TNF receptor|p80 TNF-alpha receptor|soluble TNFR1B variant 1|tumor necrosis factor beta receptor|tumor necrosis factor binding protein 2|tumor necrosis factor receptor 2|tumor necrosis factor receptor superfamily member 1B|tumor necrosis factor receptor type II
Swissprots	Q16042 B1AJZ3 P20333 Q9UIH1 Q6YI29
Accessions	AAC50622 AAD14848 AAO89076 AAP88939 BAA89052 BAA89053 BAA89054 BAA89055 CAA56324 CAI84623 CAY56003 CBX53870 CCA94575 EAW71731 EAW71732 EAW71733 EAW71734 EAW71735 P20333 AY148473 AAN72434 BC011844 AAH11844 BC042167 AAH42167 BC052977 AAH52977 BT019927 AAV38730 EU826615 ACF47651 M32315 AAA59929 M35857 AAA63262 M55994 AAA36755 S63368 AAB19824 XM_011542060 XP_011540362 XM_011542061 XP_011540363 XM_011542062 XP_011540364 XM_011542063 XP_011540365 NM_001066 NP_001057
Function	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.
Subcellular Location	Tumor necrosis factor-binding protein 2: Secreted.
Top Pathways	Cytokine-cytokine receptor interaction, Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Soluble TNF Receptor II full length protein - ab640 from Abcam Category Protein Prices $110.00, $315.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Active human TNF Receptor II protein fragment - ab168884 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human TNF Receptor II protein fragment - ab157266 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

TNF Receptor II protein (Fc Chimera Active) - ab83541 from Abcam Category Protein Prices $315.00 Sizes 25 µg Source HEK 293 cells Species Human

Human Soluble TNF Receptor II full length protein - ab132049 from Abcam Category Protein Source Wheat germ Species Human

Human TNF Receptor II peptide - ab74611 from Abcam Category Peptide

Human TNF Receptor II protein fragment - ab55577 from Abcam Category Protein Source E. coli Species Human

Human TNF Receptor II protein fragment - ab194174 from Abcam Category Protein Source HEK 293 cells Species Human

Human TNF Receptor II protein fragment - ab191762 from Abcam Category Protein Source E. coli Species Human

Human TNF Receptor II protein fragment - ab54438 from Abcam Category Protein Source E. coli Species Human

TNF Receptor II peptide - ab192471 from Abcam Category Peptide

TNFRSF1B / TNFR2 Antibody Blocking Peptide - LS-E27738 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF1B / TNFR2 Antibody Blocking Peptide - LS-E23263 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TNF RII/TNFRSF1B Protein - NBP2-35275 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

TNF RII/TNFRSF1B Recombinant Protein - H00007133-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TNF RII/TNFRSF1B Recombinant Protein - P4073 from Novus Biologicals Category Protein Prices $909.00 Sizes 20 µg Species Human

Recombinant Human TNF RII/TNFRSF1B Protein - NBP1-99359 from Novus Biologicals Category Protein Prices $190.00 Sizes 20 µg Source E. coli Species Human

TNF RII/TNFRSF1B Recombinant Protein - H00007133-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Soluble TNF Receptor II Recombinant Protein (Active) - GTX48346-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

TNF Receptor II recombinant protein - GTX65270 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source CHO cells Species Human

Recombinant Human TNF RII/TNFRSF1B Fc Chimera, CF - 726-R2-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human TNF RII/TNFRSF1B (aa 24-206) - 1089-R2-025 from R&D Systems Category Protein Source E. coli-derived, Pro24-Thr206

Recombinant Human TNF RII/TNFRSF1B (aa 24-206), CF - 1089-R2-025/CF from R&D Systems Category Protein Source E. coli-derived, Pro24-Thr206

Recombinant Mouse sTNF RII/TNFRSF1B - 426-R2-050 from R&D Systems Category Protein Source E. coli-derived, Val23-Gly258

Recombinant Mouse sTNF RII/TNFRSF1B, CF - 426-R2-050/CF from R&D Systems Category Protein Source E. coli-derived, Val23-Gly258

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