TNFRSF1B
| Gene Symbol | TNFRSF1B |
|---|---|
| Entrez Gene | 7133 |
| Alt Symbol | CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 1B |
| Other Description | TNF-R2|TNF-RII|p75 TNF receptor|p80 TNF-alpha receptor|soluble TNFR1B variant 1|tumor necrosis factor beta receptor|tumor necrosis factor binding protein 2|tumor necrosis factor receptor 2|tumor necrosis factor receptor superfamily member 1B|tumor necrosis factor receptor type II |
| Swissprots | Q16042 B1AJZ3 P20333 Q9UIH1 Q6YI29 |
| Accessions | AAC50622 AAD14848 AAO89076 AAP88939 BAA89052 BAA89053 BAA89054 BAA89055 CAA56324 CAI84623 CAY56003 CBX53870 CCA94575 EAW71731 EAW71732 EAW71733 EAW71734 EAW71735 P20333 AY148473 AAN72434 BC011844 AAH11844 BC042167 AAH42167 BC052977 AAH52977 BT019927 AAV38730 EU826615 ACF47651 M32315 AAA59929 M35857 AAA63262 M55994 AAA36755 S63368 AAB19824 XM_011542060 XP_011540362 XM_011542061 XP_011540363 XM_011542062 XP_011540364 XM_011542063 XP_011540365 NM_001066 NP_001057 |
| Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}. |
| Subcellular Location | Tumor necrosis factor-binding protein 2: Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), TNF signaling pathway |
TNF-R2 CRISPR/Cas9 KO Plasmid (h) - sc-400709 from Santa Cruz Biotechnology
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TNF-R2 HDR Plasmid (h) - sc-400709-HDR from Santa Cruz Biotechnology
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TNF-R2 Double Nickase Plasmid (h) - sc-400709-NIC from Santa Cruz Biotechnology
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TNF-R2 Double Nickase Plasmid (h2) - sc-400709-NIC-2 from Santa Cruz Biotechnology
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TNF-R2 CRISPR Activation Plasmid (h) - sc-400709-ACT from Santa Cruz Biotechnology
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TNF-R2 CRISPR Activation Plasmid (h2) - sc-400709-ACT-2 from Santa Cruz Biotechnology
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TNF-R2 Lentiviral Activation Particles (h) - sc-400709-LAC from Santa Cruz Biotechnology
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TNF-R2 Lentiviral Activation Particles (h2) - sc-400709-LAC-2 from Santa Cruz Biotechnology
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TNF-R2 siRNA (h) - sc-36689 from Santa Cruz Biotechnology
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TNF-R2 shRNA Plasmid (h) - sc-36689-SH from Santa Cruz Biotechnology
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TNF-R2 shRNA (h) Lentiviral Particles - sc-36689-V from Santa Cruz Biotechnology
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TNF RII/TNFRSF1B RNAi - H00007133-R02 from Novus Biologicals
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MISSION® esiRNA - EHU146311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21752 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21752 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11199 from Sigma-Aldrich
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TNFRSF1B siRNA (Human) - CRH4892 from Cohesion Biosciences
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TNFRSF1B - MBS8208347 from MyBioSource
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shRNA set against Human TNFRSF1B (NM_001066.2) - SHH431992 from Creative biogene
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shRNA set against Human TNFRSF1B(NM_001066.2) - SHL084944 from Creative biogene
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TNFRSF1B shRNA Plasmid (Human) - CHH4892 from Cohesion Biosciences
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TNFRSF1B miRNA 3'UTR clone - MiUTR1H-10600 from Creative biogene
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