MAPK9

Gene Symbol	MAPK9
Entrez Gene	5601
Alt Symbol	JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 9
Other Description	Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2
Swissprots	Q8N5C5 Q15708 D3DWQ9 Q15711 A8K0S3 P45984 B5M0B4 Q15710 B5BU66 D3DWQ8
Accessions	AAY46156 EAW53757 EAW53758 EAW53759 EAW53760 EAW53761 EAW53762 EAW53763 EAW53764 EAW53765 P45984 AB451302 BAG70116 AB451355 BAG70169 AB451433 BAG70247 AK289638 BAF82327 BC032539 AAH32539 BF056535 BQ025589 CR536580 CAG38817 CX758487 DB451562 DQ893713 ABM84639 EU176194 ABW03645 EU927388 ACH57450 HM036706 ADH10365 HM036707 ADH10366 HM036708 ADH10367 HM036709 ADH10368 L31951 AAA56831 U09759 AAA74740 U34821 AAC50606 U35002 AAC50608 U35003 AAC50609 XM_005265940 XP_005265997 XM_006714891 XP_006714954 XM_011534594 XP_011532896 NM_001135044 NP_001128516 NM_001308244 NP_001295173 NM_002752 NP_002743 NM_139068 NP_620707 NM_139069 NP_620708 NM_139070 NP_620709
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Herpes simplex infection, Choline metabolism in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAPK9 overexpression lysate - LY400972 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPK9 overexpression lysate - LY408411 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPK9 overexpression lysate - LY408413 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MAPK9 293 Cell Lysate - 404630 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MAPK9 293 Cell Lysate - 404631 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

MAPK9 293 Cell Lysate - 400911 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

JNK2 Overexpression Lysate (Native) - NBL1-12886 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

JNK2 Overexpression Lysate (Native) - NBP2-05607 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

JNK2 Overexpression Lysate (Native) - NBP2-05606 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

JNK2 Overexpression Lysate (Native) - NBL1-12885 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

JNK2 (h): 293T Lysate - sc-115269 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

JNK2 (h4): 293T Lysate - sc-158651 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MAPK9 Over-expression Lysate Product - GWB-D9E793 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

MAPK9 Over-expression Lysate Product - GWB-AD195F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

MAPK9 Over-expression Lysate Product - GWB-3A3325 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human JNK2 / MAPK9 Insect Cell Lysate (WB positive control) - 10745-H08BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human JNK2 Baculovirus-Insect cells Transfected Lysate (positive control) (denatured) - orb232847 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

JNK2 Overexpression Lysate (Denatured) - H00005601-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human MAPK9 Knockdown Stable Cell Line - CSC-DC009209 from Creative biogene Category Cell Line Species Human

MAPK9 KO Cell Lysate-HEK293T - CLKO-0721 from Creative biogene Category Cell Lysate

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