MAPK9

Gene Symbol	MAPK9
Entrez Gene	5601
Alt Symbol	JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 9
Other Description	Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2
Swissprots	Q8N5C5 Q15708 D3DWQ9 Q15711 A8K0S3 P45984 B5M0B4 Q15710 B5BU66 D3DWQ8
Accessions	AAY46156 EAW53757 EAW53758 EAW53759 EAW53760 EAW53761 EAW53762 EAW53763 EAW53764 EAW53765 P45984 AB451302 BAG70116 AB451355 BAG70169 AB451433 BAG70247 AK289638 BAF82327 BC032539 AAH32539 BF056535 BQ025589 CR536580 CAG38817 CX758487 DB451562 DQ893713 ABM84639 EU176194 ABW03645 EU927388 ACH57450 HM036706 ADH10365 HM036707 ADH10366 HM036708 ADH10367 HM036709 ADH10368 L31951 AAA56831 U09759 AAA74740 U34821 AAC50606 U35002 AAC50608 U35003 AAC50609 XM_005265940 XP_005265997 XM_006714891 XP_006714954 XM_011534594 XP_011532896 NM_001135044 NP_001128516 NM_001308244 NP_001295173 NM_002752 NP_002743 NM_139068 NP_620707 NM_139069 NP_620708 NM_139070 NP_620709
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Herpes simplex infection, Choline metabolism in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human JNK2 full length protein - ab132937 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source Wheat germ Species Human

Active human JNK2 full length protein - ab119726 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human JNK2 full length protein - ab130019 from Abcam Category Protein Source E. coli Species Human

Human JNK2 protein fragment - ab159219 from Abcam Category Protein Source Wheat germ Species Human

MAPK9 / JNK2 Antibody Blocking Peptide - LS-E3289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK9 / JNK2 Antibody Blocking Peptide - LS-E27842 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK9 / JNK2 Antibody Blocking Peptide - LS-E27843 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK9 / JNK2 Antibody Blocking Peptide - LS-E21088 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JNK2 Recombinant Protein - H00005601-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

JNK2 Partial Recombinant Protein - H00005601-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

JNK2 Recombinant Protein - P4711 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human JNK2 Protein - NBP1-98883 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

JNK2 Peptide - P2398 from Novus Biologicals Category Peptide Species Human

JNK2 Peptide - P2506 from Novus Biologicals Category Peptide Species Human

JNK2-MAPK9-Antibody-Center-Blocking-peptide - BP7228c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JNK2-MAPK9-Antibody-C-term-K373-Blocking-peptide - BP7506b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JNK2-MAPK9-Antibody-C-term-Blocking-peptide - BP7506a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JNK2/SAPK1 Protein (OPPA01130) - OPPA01130 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg

Human MAPK9 protein - orb246390 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human JNK2/SAPK1 protein - orb80825 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 1 μg, 5 μg Source E.coli

Human MAPK9 protein - orb168777 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

Human Mapk9 protein - orb83398 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

Goat anti MAPK9 antibody Immunizing peptide - orb66356 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Mapk9 Blocking Peptide - 33R-9445 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAPK9 protein (His tag) - 80R-2392 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

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