MAPK9

Gene Symbol	MAPK9
Entrez Gene	5601
Alt Symbol	JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 9
Other Description	Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2
Swissprots	Q8N5C5 Q15708 D3DWQ9 Q15711 A8K0S3 P45984 B5M0B4 Q15710 B5BU66 D3DWQ8
Accessions	AAY46156 EAW53757 EAW53758 EAW53759 EAW53760 EAW53761 EAW53762 EAW53763 EAW53764 EAW53765 P45984 AB451302 BAG70116 AB451355 BAG70169 AB451433 BAG70247 AK289638 BAF82327 BC032539 AAH32539 BF056535 BQ025589 CR536580 CAG38817 CX758487 DB451562 DQ893713 ABM84639 EU176194 ABW03645 EU927388 ACH57450 HM036706 ADH10365 HM036707 ADH10366 HM036708 ADH10367 HM036709 ADH10368 L31951 AAA56831 U09759 AAA74740 U34821 AAC50606 U35002 AAC50608 U35003 AAC50609 XM_005265940 XP_005265997 XM_006714891 XP_006714954 XM_011534594 XP_011532896 NM_001135044 NP_001128516 NM_001308244 NP_001295173 NM_002752 NP_002743 NM_139068 NP_620707 NM_139069 NP_620708 NM_139070 NP_620709
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Herpes simplex infection, Choline metabolism in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JNK 1/2/3 (pT183/Y185) PhosphoTracer ELISA Kit - ab119634 from Abcam Category ELISA Kit Sensitivity 50 ng/ml Range 50 ng/ml - 5000 ng/ml

JNK 1/2/3 Total PhosphoTracer ELISA Kit - ab119635 from Abcam Category ELISA Kit Sensitivity 5 ng/ml Range 5 ng/ml - 5000 ng/ml

Human/Mouse/Rat Phospho-JNK2 (T183/Y185) DuoSet IC ELISA - DYC2236-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 125.00 - 8,000 pg/mL

Human/Mouse/Rat Phospho-JNK2 (T183/Y185) DuoSet IC, 5 Plate - DYC2236-5 from R&D Systems Category ELISA Kit

Human/Mouse/Rat Total JNK2 DuoSet IC ELISA, 2 Plate - DYC1846-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 156.00 - 10,000 pg/mL

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2600454 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2600744 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2601515 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2601784 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2601531 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2600833 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2601640 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2600162 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human MAPK9 ELISA Kit - E024705 from Biobool Category ELISA Kit

Human P JNK/SAPK ELISA Kit - E029321 from Biobool Category ELISA Kit Sensitivity 1.0 pg/mL.

Anserine JNK/SAPK ELISA Kit - EAJ0008 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

anti-SAPK / JNK antibody - ARG51218 from Arigo Biolaboratories Category ELISA Kit

anti-SAPK / JNK phospho (Thr183) antibody - ARG51736 from Arigo Biolaboratories Category ELISA Kit

anti-SAPK / JNK antibody - ARG56415 from Arigo Biolaboratories Category ELISA Kit

anti-JNK2 antibody - ARG56425 from Arigo Biolaboratories Category ELISA Kit

Mitogen Activated Protein Kinase 9 (MAPK9), ELISA Kit - MBS2610007 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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