MAPK9

Gene Symbol MAPK9
Entrez Gene 5601
Alt Symbol JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 9
Other Description Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2
Swissprots Q8N5C5 Q15708 D3DWQ9 Q15711 A8K0S3 P45984 B5M0B4 Q15710 B5BU66 D3DWQ8
Accessions AAY46156 EAW53757 EAW53758 EAW53759 EAW53760 EAW53761 EAW53762 EAW53763 EAW53764 EAW53765 P45984 AB451302 BAG70116 AB451355 BAG70169 AB451433 BAG70247 AK289638 BAF82327 BC032539 AAH32539 BF056535 BQ025589 CR536580 CAG38817 CX758487 DB451562 DQ893713 ABM84639 EU176194 ABW03645 EU927388 ACH57450 HM036706 ADH10365 HM036707 ADH10366 HM036708 ADH10367 HM036709 ADH10368 L31951 AAA56831 U09759 AAA74740 U34821 AAC50606 U35002 AAC50608 U35003 AAC50609 XM_005265940 XP_005265997 XM_006714891 XP_006714954 XM_011534594 XP_011532896 NM_001135044 NP_001128516 NM_001308244 NP_001295173 NM_002752 NP_002743 NM_139068 NP_620707 NM_139069 NP_620708 NM_139070 NP_620709
Function Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}.
Top Pathways Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Herpes simplex infection, Choline metabolism in cancer, cAMP signaling pathway

JNK2 Antibody - 4672 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, C2C12, NIH/3T3, PC12, and COS cells, using JNK2 Antibody.

JNK (D-2) - sc-7345 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JNK (D-2): sc-7345. Western blot analysis of JNK expression in NIH/3T3 whole cell lysate.

JNK (FL) - sc-572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JNK (FL): sc-572. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human skin showing nuclear and cytoplasmic staining of epidermal cells.

JNK2 (N-18) - sc-827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JNK2 (N-18): sc-827. Western blot analysis of JNK2 expression in control (A), JNK2-transfected (B) and UV-irradiated (C) COS whole cell lysates.

JNK2 (A-7) - sc-271133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JNK2 (A-7): sc-271133. Western blot analysis of JNK2 expression in non-transfected: sc-117752 (A) and mouse JNK2 transfected: sc-125507 (B) 293T whole cell lysates.

JNK2 (L-12) - sc-46013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JNK2 (L-12): sc-46013. Western blot analysis of JNK2 expression in non-transfected: sc-117752 (A) and mouse JNK2 transfected: sc-125507 (B) 293T whole cell lysates.

JNK2 (D-12) - sc-46011 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-JNK (Thr 183) - sc-135642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-JNK (Thr 183): sc-135642. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear and cytoplasmic localization.

Anti-JNK2 antibody - ab178953 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab178953. Blue DAPI for nuclear staining.

Anti-JNK2 antibody - ab154902 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-JNK2 antibody (ab154902) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg

Anti-JNK2 antibody - ab69648 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JNK2 antibody (ab69648) at 1/500 dilutionLane 1 : A549 cell extractLane 2 : RAW264.7 cell extractLane 3 : A549 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-JNK2 antibody - ab88076 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-JNK2 antibody (ab88076) at 5 µg/ml + recombinant protein (immunogen) at 0.2 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

Anti-JNK2 antibody - ab78495 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab78495, at 10 µg/ml, staining JNK2 in formalin fixed, paraffin embedded brain cortex capillary.

Anti-JNK2 antibody - ab115924 from Abcam

Prices $376.00
Sizes 25 µl
Host Rabbit
Clonality Polyclonal
Anti-JNK2 antibody (ab115924) at 1/500 dilution + Mouse Brain tissue extract

Anti-JNK2 antibody - ab133158 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-JNK2 antibody (ab133158) at 0.5 µg/ml (incubation time: 1 hour) + Human cerebellum lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-JNK2 antibody - ab14045 from Abcam

Prices $370.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-JNK2 antibody - ab78234 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab78234, at 20µg/ml, staining JNK2 in human brain cortex by Immunohistochemistry using formalin-fixed, paraffin embedded tissue.

Anti-JNK2 antibody - ab57717 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-JNK2 antibody [1C1-3A8] - ab125101 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1C1-3A8
All lanes : Anti-JNK2 antibody [1C1-3A8] (ab125101) at 1/500 dilutionLane 1 : 293T cell lysate, transfected with JNK2Lane 2 : 293T cell lysate, non-transfected

Anti-JNK2 antibody [341P16] - ab19337 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 341P16
All lanes : Anti-JNK2 antibody [341P16] (ab19337) at 1 µg/mlLane 1 : Human jurkat cellsLane 2 : Mouse 3T3-L1 cellsLane 3 : Rat PC-12 Cells

Anti-JNK2 antibody [EP1595Y] - ab76125 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1595Y
JNK2 was immunoprecipitated using 0.5mg Hela whole cell extract, 5µg of Rabbit monoclonal to JNK2 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, Hela whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab76125.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 48kDa; JNK2

Anti-JNK2 antibody - C-terminal - ab72095 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-JNK2 antibody - C-terminal (ab72095) at 1/100 dilution + Jurkat cell lysate at 12.5 µgSecondaryHRP-anti-rabbit

Anti-MAPK9 / JNK2 Antibody (clone 4D1) - LS-C174575 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D1
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

Anti-MAPK9 / JNK2 Antibody (clone 2H3) - LS-C174557 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H3
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-MAPK9 mouse monoclonal antibody.

Anti-MAPK9 / JNK2 Antibody (clone 1C1-3A8) IHC-plus™ - LS-B6137 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C1-3A8
Anti-MAPK9 / JNK2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6137 concentration 5 ug/ml.
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