MAPK9

Gene Symbol	MAPK9
Entrez Gene	5601
Alt Symbol	JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 9
Other Description	Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2
Swissprots	Q8N5C5 Q15708 D3DWQ9 Q15711 A8K0S3 P45984 B5M0B4 Q15710 B5BU66 D3DWQ8
Accessions	AAY46156 EAW53757 EAW53758 EAW53759 EAW53760 EAW53761 EAW53762 EAW53763 EAW53764 EAW53765 P45984 AB451302 BAG70116 AB451355 BAG70169 AB451433 BAG70247 AK289638 BAF82327 BC032539 AAH32539 BF056535 BQ025589 CR536580 CAG38817 CX758487 DB451562 DQ893713 ABM84639 EU176194 ABW03645 EU927388 ACH57450 HM036706 ADH10365 HM036707 ADH10366 HM036708 ADH10367 HM036709 ADH10368 L31951 AAA56831 U09759 AAA74740 U34821 AAC50606 U35002 AAC50608 U35003 AAC50609 XM_005265940 XP_005265997 XM_006714891 XP_006714954 XM_011534594 XP_011532896 NM_001135044 NP_001128516 NM_001308244 NP_001295173 NM_002752 NP_002743 NM_139068 NP_620707 NM_139069 NP_620708 NM_139070 NP_620709
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Herpes simplex infection, Choline metabolism in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JNK2 CRISPR/Cas9 KO Plasmid (h) - sc-400115 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 HDR Plasmid (h) - sc-400115-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 Double Nickase Plasmid (h) - sc-400115-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 Double Nickase Plasmid (h2) - sc-400115-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 CRISPR Activation Plasmid (h) - sc-400115-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 CRISPR Activation Plasmid (h2) - sc-400115-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 Lentiviral Activation Particles (h) - sc-400115-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 Lentiviral Activation Particles (h2) - sc-400115-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JNK2 siRNA (h) - sc-39101 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JNK2 shRNA Plasmid (h) - sc-39101-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JNK2 shRNA (h) Lentiviral Particles - sc-39101-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JNK2 RNAi - H00005601-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

JNK2 RNAi - H00005601-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

JNK2 RNAi - H00005601-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

JNK2 RNAi - H00005601-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

JNK2 RNAi - H00005601-R08 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU080681 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1222 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1224 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1223 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN13019 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13019 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05908 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05908

MAPK9 siRNA (Human) - CRH3771 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MAPK9 (NM_002752.4) - SHH338123 from Creative biogene Category siRNA Species Reactivities Human

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