| Gene Symbol |
CETN2
|
| Entrez Gene |
1069
|
| Alt Symbol |
CALT, CEN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centrin, EF-hand protein, 2
|
| Other Description |
caltractin (20kD calcium-binding protein)|centrin-2
|
| Swissprots |
Q53XW1 B2R4T4 P41208
|
| Accessions |
AAW82436 EAW72900 P41208 AK311940 BAG34881 AM393039 CAL37917 BC005334 AAH05334 BC013873 AAH13873 BT007256 AAP35920 X72964 CAA51467 NM_004344 NP_004335
|
| Function |
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn rec
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus {ECO:0000305}. Note=Centrosome of S-phase, interphase and mitotic cells.
|
| Top Pathways |
Nucleotide excision repair
|
