Gene Symbol | CETN2 |
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Entrez Gene | 1069 |
Alt Symbol | CALT, CEN2 |
Species | Human |
Gene Type | protein-coding |
Description | centrin, EF-hand protein, 2 |
Other Description | caltractin (20kD calcium-binding protein)|centrin-2 |
Swissprots | Q53XW1 B2R4T4 P41208 |
Accessions | AAW82436 EAW72900 P41208 AK311940 BAG34881 AM393039 CAL37917 BC005334 AAH05334 BC013873 AAH13873 BT007256 AAP35920 X72964 CAA51467 NM_004344 NP_004335 |
Function | The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn rec |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus {ECO:0000305}. Note=Centrosome of S-phase, interphase and mitotic cells. |
Top Pathways | Nucleotide excision repair |
Centrin-2 CRISPR/Cas9 KO Plasmid (h) - sc-400867 from Santa Cruz Biotechnology
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Centrin-2 HDR Plasmid (h) - sc-400867-HDR from Santa Cruz Biotechnology
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Centrin-2 Double Nickase Plasmid (h) - sc-400867-NIC from Santa Cruz Biotechnology
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Centrin-2 Double Nickase Plasmid (h2) - sc-400867-NIC-2 from Santa Cruz Biotechnology
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Centrin-2 CRISPR Activation Plasmid (h) - sc-400867-ACT from Santa Cruz Biotechnology
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Centrin-2 CRISPR Activation Plasmid (h2) - sc-400867-ACT-2 from Santa Cruz Biotechnology
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Centrin-2 Lentiviral Activation Particles (h) - sc-400867-LAC from Santa Cruz Biotechnology
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Centrin-2 Lentiviral Activation Particles (h2) - sc-400867-LAC-2 from Santa Cruz Biotechnology
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Centrin-2 siRNA (h) - sc-43681 from Santa Cruz Biotechnology
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Centrin-2 shRNA Plasmid (h) - sc-43681-SH from Santa Cruz Biotechnology
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Centrin-2 shRNA (h) Lentiviral Particles - sc-43681-V from Santa Cruz Biotechnology
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Centrin 2 RNAi - H00001069-R01 from Novus Biologicals
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MISSION® esiRNA - EHU137031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5991 from Sigma-Aldrich
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CETN2 siRNA (Human) - CRH0770 from Cohesion Biosciences
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CETN2 - MBS8237354 from MyBioSource
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Centrin-2 CRISPR/Cas9 KO Plasmid (h2) - sc-400867-KO-2 from Santa Cruz Biotechnology
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Centrin-2 HDR Plasmid (h2) - sc-400867-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CETN2 (NM_004344.1) - SHH262329 from Creative biogene
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shRNA set against Human CETN2(NM_004344.1) - SHG169179 from Creative biogene
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Human CETN2 siRNA - orb261272 from Biorbyt
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CETN2 shRNA Plasmid (Human) - CHH0770 from Cohesion Biosciences
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CETN2 miRNA 3'UTR clone - MiUTR1H-02069 from Creative biogene
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