| Gene Symbol |
PABPC1
|
| Entrez Gene |
26986
|
| Alt Symbol |
PAB1, PABP, PABP1, PABPC2, PABPL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly(A) binding protein, cytoplasmic 1
|
| Other Description |
poly(A) binding protein, cytoplasmic 2|polyadenylate-binding protein 1
|
| Swissprots |
Q15097 Q93004 P11940
|
| Accessions |
AAD08718 CBX53830 EAW91814 EAW91815 EAW91816 EAW91817 EAW91818 EAW91819 EAW91820 EAW91821 P11940 AK095194 BAG53005 AK130523 AK298990 BAG61082 AK303120 BAG64226 AL135187 BC015958 AAH15958 BC023217 BC023520 AAH23520 BC041863 DQ893508 ABM84434 DQ896500 ABM87499 KC832802 Y00345 CAA68428 Z48501 CAA88401 XM_005250861 XP_005250918 NM_002568 NP_002559
|
| Function |
Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:2057
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RNA degradation, RNA transport, mRNA surveillance pathway
|
