PABPC1

Gene Symbol PABPC1
Entrez Gene 26986
Alt Symbol PAB1, PABP, PABP1, PABPC2, PABPL1
Species Human
Gene Type protein-coding
Description poly(A) binding protein, cytoplasmic 1
Other Description poly(A) binding protein, cytoplasmic 2|polyadenylate-binding protein 1
Swissprots Q15097 Q93004 P11940
Accessions AAD08718 CBX53830 EAW91814 EAW91815 EAW91816 EAW91817 EAW91818 EAW91819 EAW91820 EAW91821 P11940 AK095194 BAG53005 AK130523 AK298990 BAG61082 AK303120 BAG64226 AL135187 BC015958 AAH15958 BC023217 BC023520 AAH23520 BC041863 DQ893508 ABM84434 DQ896500 ABM87499 KC832802 Y00345 CAA68428 Z48501 CAA88401 XM_005250861 XP_005250918 NM_002568 NP_002559
Function Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:2057
Subcellular Location Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.
Tissue Specificity Ubiquitous.
Top Pathways RNA degradation, RNA transport, mRNA surveillance pathway

Asymmetric-Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb - 3505 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C60A10
Western blot analysis of extracts from various cell lines using Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb. As expected, PABP1 methylation is decreased in CARM1 knockout (-/-) mouse embryo fibroblasts (MEFs).

PABP1 Antibody - 4992 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-29 cells, using PABP1 Antibody.

PABP (A-4) - sc-166381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PABP (A-4): sc-166381. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

PABP (F-2) - sc-166027 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PABP (F-2): sc-166027. Western blot analysis of PABP expression in non-transfected 293T: sc-117752 (A), human PABP transfected 293T: sc-170011 (B) and NTERA-2 cl.D1 (C) whole cell lysates.

PABP (F-20) - sc-18611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PABP (F-20): sc-18611. Western blot analysis of PABP expression in mouse testis extract.

PABP (H-300) - sc-28834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PABP (H-300): sc-28834. Western blot analysis of PABP expression in mouse testis tissue extract.

PABP (N-20) - sc-18610 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PABP (N-20): sc-18610. Western blot analysis of PABP expression in non-transfected: sc-117752 (A) and human PABP transfected: sc-116998 (B) 293T whole cell lysates.

PABP (10E10) - sc-32318 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PABP (10E10): sc-32318. Western blot analysis of PABP expression in NTERA-2 cl.D1 whole cell lysate.

Anti-PABP antibody - ab21060 from Abcam

Prices $404.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PABP antibody (ab21060) at 1 µg/ml + HeLa whole cell lysate at 20 µg/mlSecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-PABP antibody - ab153930 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PABP antibody (ab153930) at 1/1000 dilutionLane 1 : A549 whole cell lysateLane 2 : H1299 whole cell lysateLane 3 : HCT116 whole cell lysateLane 4 : MCF7 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-PABP antibody - ab85770 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PABP antibody (ab85770) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-PABP antibody - ab76761 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PABP antibody [10E10] - ab6125 from Abcam

Prices $401.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10E10
All lanes : Anti-PABP antibody [10E10] (ab6125) at 1/2000 dilutionLane 1 : 10ug of protein from MCF10A cells transfected with negative control siRNA.Lane 2 : 10ug of protein from MCF10A cells transfected with PABP specific siRNA.Lane 3 : 10 ug of protein from MCF10A cells transfected with PABP specific siRNA.SecondaryGoat anti-mouse 1/10000

Anti-PABPC1 / PABP1 Antibody (clone 10E10) - LS-C82229 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10E10

Anti-PABPC1 / PABP1 Antibody - LS-C92012 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PABPC1 / PABP1 Antibody (Internal) - LS-C144925 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PABPC1 / PABP1 Antibody (clone 10E10) - LS-C82271 from LifeSpan Bioscience

Prices $380.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 10E10
Immunocytochemistry/ Immunofluorescence-PABP antibody [10E10] stained HeLa cells

Anti-PABPC1 / PABP1 Antibody (Internal) IHC-plus™ - LS-B8470 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PABPC1 / PABP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8470 dilution 5-10 ug/ml.

Anti-PABPC1 / PABP1 Antibody (aa431-480) - LS-C101839 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PABPC1 / PABP antibody LS-C101839 Western blot of HepG2 cell lysate.

Anti-PABPC1 / PABP1 Antibody - LS-C330978 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse testis, using PABPC1 antibody.

Anti-PABPC1 / PABP1 Antibody (aa250-279) - LS-C163331 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

PABP Antibody (10E10) - NB120-6125 from Novus Biologicals

Prices $129.00, $329.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone 10E10
Western Blot: PABP Antibody (10E10) [NB120-6125] - Analysis of PABP expression in 1) A-431, 2) HeLa and 3) NIH-3T3 whole cell lysates.

PABP Antibody - NBP2-19670 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PABP Antibody [NBP2-19670] - Sample (30 ug of whole cell lysate) A: A549 B: H1299 C: HCT116 D: MCF-7 7. 5% SDS PAGE gel, diluted at 1:1000.

PABP Antibody - NBP1-57154 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PABP Antibody - NBP1-31840 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PABP Antibody [NBP1-31840] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:5000.
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