PABPC1

Gene Symbol	PABPC1
Entrez Gene	26986
Alt Symbol	PAB1, PABP, PABP1, PABPC2, PABPL1
Species	Human
Gene Type	protein-coding
Description	poly(A) binding protein, cytoplasmic 1
Other Description	poly(A) binding protein, cytoplasmic 2|polyadenylate-binding protein 1
Swissprots	Q15097 Q93004 P11940
Accessions	AAD08718 CBX53830 EAW91814 EAW91815 EAW91816 EAW91817 EAW91818 EAW91819 EAW91820 EAW91821 P11940 AK095194 BAG53005 AK130523 AK298990 BAG61082 AK303120 BAG64226 AL135187 BC015958 AAH15958 BC023217 BC023520 AAH23520 BC041863 DQ893508 ABM84434 DQ896500 ABM87499 KC832802 Y00345 CAA68428 Z48501 CAA88401 XM_005250861 XP_005250918 NM_002568 NP_002559
Function	Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:2057
Subcellular Location	Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.
Tissue Specificity	Ubiquitous.
Top Pathways	RNA degradation, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PABP peptide - ab23710 from Abcam Category Peptide

PABPC1 / PABP1 Antibody Blocking Peptide - LS-E7203 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PABP Protein - H00026986-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PABPC1-Antibody-Center-Blocking-Peptide - BP2920c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PABPC1 protein - orb244425 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PABPC1 Blocking Peptide - 33R-5379 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PABPC1 - H00026986-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PABPC1,PABP fusion protein - ag1422 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PABPC1, His-tagged - PABPC1-30620TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Polyadenylate-binding protein 1(PABPC1) - CSB-YP017352HU CSB-BP017352HU CSB-MP017352HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Polyadenylate-binding protein 1 - CSB-EP017352HU from Cusabio Category Protein Source E.coli Species Human

PABPC1 - TP307354 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PABPC1, Recombinant Protein - MBS5304168 from MyBioSource Category Protein Prices $745.00 Sizes 250 µg Source E Coli

Polyadenylate-binding protein 1, Recombinant Protein - MBS960232 from MyBioSource Category Protein Prices $185.00, $420.00, $680.00, $1,070.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human PABPC1 protein, MYC/DDK-tagged - PABPC1-649H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human PABPC1 protein, GST-tagged - PABPC1-648H from Creative Biomart Category Protein Source Wheat Germ Species Human

PABPC1-Antibody-N-term-Blocking-Peptide - BP2920a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PABPC1 Peptide, Human - M34GP11221H from Creative Peptides Category Peptide Source Synthetic. Species Human

PABPC1 Recombinant Protein (OPCA01775) - OPCA01775 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Polyadenylate-binding protein 1 - AP70615 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

PABP Recombinant Protein Antigen - NBP2-57869PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Polyadenylate-binding protein 1, Recombinant Protein - MBS9420521 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Recombinant Human PABPC1 Protein (1-370 aa), His-SUMO-tagged - PABPC1-707H from Creative Biomart Category Protein Source E. coli Species Human

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