PABPC1

Gene Symbol	PABPC1
Entrez Gene	26986
Alt Symbol	PAB1, PABP, PABP1, PABPC2, PABPL1
Species	Human
Gene Type	protein-coding
Description	poly(A) binding protein, cytoplasmic 1
Other Description	poly(A) binding protein, cytoplasmic 2|polyadenylate-binding protein 1
Swissprots	Q15097 Q93004 P11940
Accessions	AAD08718 CBX53830 EAW91814 EAW91815 EAW91816 EAW91817 EAW91818 EAW91819 EAW91820 EAW91821 P11940 AK095194 BAG53005 AK130523 AK298990 BAG61082 AK303120 BAG64226 AL135187 BC015958 AAH15958 BC023217 BC023520 AAH23520 BC041863 DQ893508 ABM84434 DQ896500 ABM87499 KC832802 Y00345 CAA68428 Z48501 CAA88401 XM_005250861 XP_005250918 NM_002568 NP_002559
Function	Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:2057
Subcellular Location	Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.
Tissue Specificity	Ubiquitous.
Top Pathways	RNA degradation, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PABPC1-cDNA-Clone - DC04240 from Abgent, a WuXi AppTec company Prices $858.60 Sizes 10 µg Species Human Accession BC015958

PABPC1 - MBS1269352 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015958

Human PABPC1 cDNA clone(NM_002568.3) - CDFH013578 from Creative Biomart Species Human Accession NM_002568.3

Human PABPC1 ORF clone(NM_002568.3) - CDCL185594 from Creative Biomart Species Human Accession NM_002568.3

Human PABPC1 ORF Clone(NM_002568.3) - CDCR283530 from Creative Biomart Species Human Accession NM_002568.3

Human PABPC1 ORF Clone(NM_002568.3) - CDCR283531 from Creative Biomart Species Human Accession NM_002568.3

Human PABPC1 Gene ORF cDNA clone in cloning vector - HG13781-G from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13781-ANG from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13781-NY from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13781-ACG from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13781-NF from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13781-ACR from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13781-ANR from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13781-NM from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13781-CF from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13781-CM from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13781-NH from Sino Biological Species Human

Human PABPC1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13781-CY from Sino Biological Species Human

Human PABPC1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG13781-UT from Sino Biological Species Human Accession NM_002568.3

Human PABPC1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13781-CH from Sino Biological Species Human

Human PABPC1 ORF clone(NM_002568.3) - CDCL185594 from Creative biogene Species Human

Human PABPC1 ORF Clone (BC015958) - CDCS410843 from Creative biogene Species Human Accession P11940

Human PABPC1 cDNA Clone(NM_002568.3) - CDFH013578 from Creative biogene Species Human

Search more