| Gene Symbol | CBX7 |
|---|---|
| Entrez Gene | 23492 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromobox homolog 7 |
| Other Description | chromobox protein homolog 7 |
| Swissprots | O95931 Q86T17 |
| Accessions | EAW60297 EAW60298 EAW60299 EAW60300 EAW60301 O95931 AK124408 BC051773 AAH51773 BC128418 DQ064603 AAY68391 EU446785 ABZ92314 XM_005261413 XP_005261470 XM_006724174 XP_006724237 XM_006724175 XP_006724238 XM_006724176 XP_006724239 XM_006724177 XP_006724240 XM_006724178 XP_006724241 XM_011530025 XP_011528327 NM_175709 NP_783640 |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. {ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21047797, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}. |
Human-CBX7-cDNA-Clone - DC07876 from Abgent, a WuXi AppTec company
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CBX7 cDNA (ANA10826) - ANA10826 from Aviva Systems Biology
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CBX7 - MBS1275823 from MyBioSource
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Human CBX7 ORF Clone (BC051773) - CDCS417505 from Creative biogene
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