Gene Symbol | CBX7 |
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Entrez Gene | 23492 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | chromobox homolog 7 |
Other Description | chromobox protein homolog 7 |
Swissprots | O95931 Q86T17 |
Accessions | EAW60297 EAW60298 EAW60299 EAW60300 EAW60301 O95931 AK124408 BC051773 AAH51773 BC128418 DQ064603 AAY68391 EU446785 ABZ92314 XM_005261413 XP_005261470 XM_006724174 XP_006724237 XM_006724175 XP_006724238 XM_006724176 XP_006724239 XM_006724177 XP_006724240 XM_006724178 XP_006724241 XM_011530025 XP_011528327 NM_175709 NP_783640 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. {ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21047797, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}. |
CBX7 CRISPR/Cas9 KO Plasmid (h) - sc-402903 from Santa Cruz Biotechnology
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CBX7 HDR Plasmid (h) - sc-402903-HDR from Santa Cruz Biotechnology
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CBX7 Double Nickase Plasmid (h) - sc-402903-NIC from Santa Cruz Biotechnology
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CBX7 Double Nickase Plasmid (h2) - sc-402903-NIC-2 from Santa Cruz Biotechnology
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CBX7 CRISPR Activation Plasmid (h) - sc-402903-ACT from Santa Cruz Biotechnology
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CBX7 CRISPR Activation Plasmid (h2) - sc-402903-ACT-2 from Santa Cruz Biotechnology
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CBX7 Lentiviral Activation Particles (h) - sc-402903-LAC from Santa Cruz Biotechnology
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CBX7 Lentiviral Activation Particles (h2) - sc-402903-LAC-2 from Santa Cruz Biotechnology
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CBX7 siRNA (h) - sc-72816 from Santa Cruz Biotechnology
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CBX7 shRNA Plasmid (h) - sc-72816-SH from Santa Cruz Biotechnology
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CBX7 shRNA (h) Lentiviral Particles - sc-72816-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU035461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5431 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13822 from Sigma-Aldrich
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CBX7 siRNA (Human) - CRH8303 from Cohesion Biosciences
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CBX7 - MBS8219142 from MyBioSource
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shRNA set against Human CBX7 (NM_175709.3) - SHH255557 from Creative biogene
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shRNA set against Human CBX7(NM_175709.3) - SHG145639 from Creative biogene
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CBX7 CRISPR/Cas9 KO Plasmid (h2) - sc-402903-KO-2 from Santa Cruz Biotechnology
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CBX7 HDR Plasmid (h2) - sc-402903-HDR-2 from Santa Cruz Biotechnology
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Human CBX7 siRNA - orb268805 from Biorbyt
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CBX7 shRNA Plasmid (Human) - CHH8303 from Cohesion Biosciences
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CBX7 miRNA 3'UTR clone - MiUTR1H-01712 from Creative biogene
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