FBLIM1

Gene Symbol FBLIM1
Entrez Gene 54751
Alt Symbol CAL, FBLP-1, FBLP1
Species Human
Gene Type protein-coding
Description filamin binding LIM protein 1
Other Description CSX-associated LIM|MIG2-interacting protein|filamin-binding LIM protein 1|filamin-binding LIM protein-1|migfilin|mitogen-inducible 2 interacting protein|mitogen-inducible 2-interacting protein
Swissprots Q9UFD6 Q5VVE1 Q96T00 Q8IX23 Q5VVE0 B3KNY0 Q8WUP2
Accessions EAW51750 EAW51751 EAW51752 Q8WUP2 AF459643 AAO15549 AK027444 BAB55115 AK055259 BAG51492 AL133035 CAB61365 AY180161 AAO49012 BC019895 AAH19895 BM855570 CN278745 DQ891730 ABM82656 DQ894907 ABM85833 XM_005245900 XP_005245957 XM_005245901 XP_005245958 XM_005245902 XP_005245959 XM_005245903 XP_005245960 XM_005245909 XP_005245966 XM_006710704 XP_006710767 XM_006710705 XP_006710768 XM_011541616 XP_011539918 XM_011541617 XP_011539919 XM_011541618 XP_011539920 XM_011541619 XP_011539921 XR_946670 NM_001024215 NP_001019386 NM_001024216 NP_001019387 NM_017556 NP_060026
Function Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.
Subcellular Location Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers.
Tissue Specificity Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}.

FBLIM1 (G-7) - sc-271417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FBLIM1 (G-7): sc-271417. Western blot analysis of FBLIM1 expression in WI 38 whole cell lysate.

FBLIM1 (H-73) - sc-134724 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FBLIM1 (H-73): sc-134724. Western blot analysis of FBLIM1 expression in WI 38 whole cell lysate.

FBLIM1 (N-12) - sc-162822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBLIM1 (N-12): sc-162822. Immunofluorescence staining of formalin-fixed HepG2 cells showing cytoskeletal localization.

FBLIM1 (T-15) - sc-162823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBLIM1 (T-15): sc-162823. Immunofluorescence staining of formalin-fixed HepG2 cells showing cytoskeletal localization.

Anti-FBLIM1 antibody - ab76673 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-FBLIM1 antibody (ab76673) at 1 µg/ml + Recombinant tagged human FBLIM1 fragment at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-FBLIM1 antibody - ab112590 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FBLIM1 antibody (ab112590) at 1/100 dilution + A549 cell line lysate at 35 µg

Anti-FBLIM1 antibody - ab172795 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-FBLIM1 antibody (ab172795) at 1 µg/mlLane 1 : FBLIM1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-FBLIM1 / Migfilin Antibody - LS-C129092 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FBLIM1 / Migfilin Antibody (aa270-374, clone 10C250, Azide-free) - LS-C183628 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C250

Anti-FBLIM1 / Migfilin Antibody (aa301-331, AP) - LS-C235187 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (aa301-331, APC) - LS-C235188 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (aa301-331, Biotin) - LS-C235189 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (clone 3F8) - LS-C139196 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F8
FBLIM1 monoclonal antibody (M03), clone 3F8. Western blot of FBLIM1 expression in HepG2.

Anti-FBLIM1 / Migfilin Antibody (aa301-331, FITC) - LS-C235190 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (aa301-331, PE) - LS-C235192 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (aa301-331, Azide-free, HRP) - LS-C249963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (aa301-331) - LS-C321298 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBLIM1 / Migfilin Antibody (aa1-242, clone 3F8) - LS-C340224 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBLIM1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBLIM1.

Anti-FBLIM1 / Migfilin Antibody (aa301-331) - LS-C166062 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FBLIM1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-FBLIM1 / Migfilin Antibody (aa1-242, clone 3G1) - LS-C340227 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G1
Western blot of extracts (10ug) from 2 different cell lines by using anti-FBLIM1 monoclonal antibody at 1:200 dilution.

Migfilin Antibody - NBP1-86665 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Migfilin Antibody [NBP1-86665] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Migfilin Antibody (5E11) - H00054751-M10 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5E11
Western Blot: Migfilin Antibody (5E11) [H00054751-M10] - Analysis of FBLIM1 expression in HepG2 (Cat # L019V1).

Migfilin Antibody - NBP2-17291 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Migfilin Antibody [NBP2-17291] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000.

Migfilin Antibody (3F8) - H00054751-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F8
Western Blot: Migfilin Antibody (3F8) [H00054751-M03] - Analysis of FBLIM1 expression in HepG2 (Cat # L019V1).

Migfilin Antibody - H00054751-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal
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