FBLIM1

Gene Symbol FBLIM1
Entrez Gene 54751
Alt Symbol CAL, FBLP-1, FBLP1
Species Human
Gene Type protein-coding
Description filamin binding LIM protein 1
Other Description CSX-associated LIM|MIG2-interacting protein|filamin-binding LIM protein 1|filamin-binding LIM protein-1|migfilin|mitogen-inducible 2 interacting protein|mitogen-inducible 2-interacting protein
Swissprots Q9UFD6 Q5VVE1 Q96T00 Q8IX23 Q5VVE0 B3KNY0 Q8WUP2
Accessions EAW51750 EAW51751 EAW51752 Q8WUP2 AF459643 AAO15549 AK027444 BAB55115 AK055259 BAG51492 AL133035 CAB61365 AY180161 AAO49012 BC019895 AAH19895 BM855570 CN278745 DQ891730 ABM82656 DQ894907 ABM85833 XM_005245900 XP_005245957 XM_005245901 XP_005245958 XM_005245902 XP_005245959 XM_005245903 XP_005245960 XM_005245909 XP_005245966 XM_006710704 XP_006710767 XM_006710705 XP_006710768 XM_011541616 XP_011539918 XM_011541617 XP_011539919 XM_011541618 XP_011539920 XM_011541619 XP_011539921 XR_946670 NM_001024215 NP_001019386 NM_001024216 NP_001019387 NM_017556 NP_060026
Function Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.
Subcellular Location Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers.
Tissue Specificity Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}.

FBLIM1 CRISPR/Cas9 KO Plasmid (h) - sc-412324 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 HDR Plasmid (h) - sc-412324-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 Double Nickase Plasmid (h) - sc-412324-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 Double Nickase Plasmid (h2) - sc-412324-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 CRISPR Activation Plasmid (h) - sc-412324-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 CRISPR Activation Plasmid (h2) - sc-412324-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 Lentiviral Activation Particles (h) - sc-412324-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 Lentiviral Activation Particles (h2) - sc-412324-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBLIM1 siRNA (h) - sc-88837 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBLIM1 shRNA Plasmid (h) - sc-88837-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBLIM1 shRNA (h) Lentiviral Particles - sc-88837-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Migfilin RNAi - H00054751-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Migfilin RNAi - H00054751-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8502 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8502 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBLIM1 siRNA (Human) - CRJ0195 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Migfilin RNAi - H00054751-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FBLIM1 - MBS8217598 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBLIM1 (NM_017556.2) - SHH292665 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FBLIM1(NM_017556.2) - SHH050141 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FBLIM1(NM_001024215.1) - SHH050159 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FBLIM1(NM_001024216.1) - SHH050177 from Creative biogene

Category siRNA
Species Reactivities Human

FBLIM1 shRNA Plasmid (Human) - CHJ0195 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBLIM1 miRNA 3'UTR clone - MiUTR1H-03526 from Creative biogene

Species Reactivities Human
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