| Gene Symbol |
FBLIM1
|
| Entrez Gene |
54751
|
| Alt Symbol |
CAL, FBLP-1, FBLP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
filamin binding LIM protein 1
|
| Other Description |
CSX-associated LIM|MIG2-interacting protein|filamin-binding LIM protein 1|filamin-binding LIM protein-1|migfilin|mitogen-inducible 2 interacting protein|mitogen-inducible 2-interacting protein
|
| Swissprots |
Q9UFD6 Q5VVE1 Q96T00 Q8IX23 Q5VVE0 B3KNY0 Q8WUP2
|
| Accessions |
EAW51750 EAW51751 EAW51752 Q8WUP2 AF459643 AAO15549 AK027444 BAB55115 AK055259 BAG51492 AL133035 CAB61365 AY180161 AAO49012 BC019895 AAH19895 BM855570 CN278745 DQ891730 ABM82656 DQ894907 ABM85833 XM_005245900 XP_005245957 XM_005245901 XP_005245958 XM_005245902 XP_005245959 XM_005245903 XP_005245960 XM_005245909 XP_005245966 XM_006710704 XP_006710767 XM_006710705 XP_006710768 XM_011541616 XP_011539918 XM_011541617 XP_011539919 XM_011541618 XP_011539920 XM_011541619 XP_011539921 XR_946670 NM_001024215 NP_001019386 NM_001024216 NP_001019387 NM_017556 NP_060026
|
| Function |
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.
|
| Subcellular Location |
Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers.
|
| Tissue Specificity |
Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}.
|
![Western Blot: Migfilin Overexpression Lysate (Adult Normal) [NBL1-10608] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Migfilin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10000_Migfilin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10608-img0002.jpg)