| Gene Symbol | FBLIM1 |
|---|---|
| Entrez Gene | 54751 |
| Alt Symbol | CAL, FBLP-1, FBLP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | filamin binding LIM protein 1 |
| Other Description | CSX-associated LIM|MIG2-interacting protein|filamin-binding LIM protein 1|filamin-binding LIM protein-1|migfilin|mitogen-inducible 2 interacting protein|mitogen-inducible 2-interacting protein |
| Swissprots | Q9UFD6 Q5VVE1 Q96T00 Q8IX23 Q5VVE0 B3KNY0 Q8WUP2 |
| Accessions | EAW51750 EAW51751 EAW51752 Q8WUP2 AF459643 AAO15549 AK027444 BAB55115 AK055259 BAG51492 AL133035 CAB61365 AY180161 AAO49012 BC019895 AAH19895 BM855570 CN278745 DQ891730 ABM82656 DQ894907 ABM85833 XM_005245900 XP_005245957 XM_005245901 XP_005245958 XM_005245902 XP_005245959 XM_005245903 XP_005245960 XM_005245909 XP_005245966 XM_006710704 XP_006710767 XM_006710705 XP_006710768 XM_011541616 XP_011539918 XM_011541617 XP_011539919 XM_011541618 XP_011539920 XM_011541619 XP_011539921 XR_946670 NM_001024215 NP_001019386 NM_001024216 NP_001019387 NM_017556 NP_060026 |
| Function | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}. |
| Subcellular Location | Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers. |
| Tissue Specificity | Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}. |
Human FBLIM1 Gene cDNA Clone - orb143145 from Biorbyt
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FBLIM1 - MBS1271018 from MyBioSource
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Human FBLIM1 cDNA clone(NM_017556.2) - CDFG000831 from Creative Biomart
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Human FBLIM1 cDNA clone(NM_001024216.1) - CDFH006633 from Creative Biomart
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Human FBLIM1 cDNA clone(NM_001024215.1) - CDFH006634 from Creative Biomart
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Mouse FBLIM1 ORF clone - CDCL106947 from Creative Biomart
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Mouse FBLIM1 ORF clone - CDCL106948 from Creative Biomart
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Human FBLIM1 ORF clone - CDCL106949 from Creative Biomart
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Human FBLIM1 ORF clone - CDCL106950 from Creative Biomart
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Human FBLIM1 ORF clone - CDCL106951 from Creative Biomart
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Human FBLIM1 ORF clone - CDCL106952 from Creative Biomart
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Human FBLIM1 ORF clone - CDCL106953 from Creative Biomart
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Human FBLIM1 ORF clone - CDCL106954 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_001024215.1) - CDCL163175 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_017556.2) - CDCR301942 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_017556.2) - CDCR301943 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_017556.2) - CDCR301944 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_001024215.1) - CDCR342156 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_001024215.1) - CDCR342157 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_001024216.1) - CDCR342158 from Creative Biomart
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Human FBLIM1 ORF Clone(NM_001024216.1) - CDCR342159 from Creative Biomart
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Human FBLIM1 Gene cDNA Clone (full-length ORF Clone) - HG14745-G from Sino Biological
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Human FBLIM1 Gene ORF cDNA clone expression plasmid - HG14745-UT from Sino Biological
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Human FBLIM1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14745-CY from Sino Biological
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Human FBLIM1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14745-ACR from Sino Biological
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