FBLIM1

Gene Symbol	FBLIM1
Entrez Gene	54751
Alt Symbol	CAL, FBLP-1, FBLP1
Species	Human
Gene Type	protein-coding
Description	filamin binding LIM protein 1
Other Description	CSX-associated LIM|MIG2-interacting protein|filamin-binding LIM protein 1|filamin-binding LIM protein-1|migfilin|mitogen-inducible 2 interacting protein|mitogen-inducible 2-interacting protein
Swissprots	Q9UFD6 Q5VVE1 Q96T00 Q8IX23 Q5VVE0 B3KNY0 Q8WUP2
Accessions	EAW51750 EAW51751 EAW51752 Q8WUP2 AF459643 AAO15549 AK027444 BAB55115 AK055259 BAG51492 AL133035 CAB61365 AY180161 AAO49012 BC019895 AAH19895 BM855570 CN278745 DQ891730 ABM82656 DQ894907 ABM85833 XM_005245900 XP_005245957 XM_005245901 XP_005245958 XM_005245902 XP_005245959 XM_005245903 XP_005245960 XM_005245909 XP_005245966 XM_006710704 XP_006710767 XM_006710705 XP_006710768 XM_011541616 XP_011539918 XM_011541617 XP_011539919 XM_011541618 XP_011539920 XM_011541619 XP_011539921 XR_946670 NM_001024215 NP_001019386 NM_001024216 NP_001019387 NM_017556 NP_060026
Function	Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.
Subcellular Location	Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers.
Tissue Specificity	Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBLIM1 full length protein - ab156959 from Abcam Category Protein Source E. coli Species Human

Human FBLIM1 protein fragment - ab162831 from Abcam Category Protein Source Wheat germ Species Human

FBLIM1 / Migfilin Antibody Blocking Peptide - LS-E1885 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Migfilin Partial Recombinant Protein - H00054751-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Migfilin Protein - NBP2-23053 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E.coli Species Human

FBLIM1-Antibody-C-term-Blocking-peptide - BP12719b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human FBLIM1 protein - orb191178 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

FBLIM1 protein (His tag) - 80R-2818 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

FBLIM1 (1-373, His-tag) - AR50937PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

FBLIM1 (1-373, His-tag) - AR50937PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

FBLIM1 - H00054751-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBLIM1 - H00054751-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBLIM1, 1-373aa, Human, His tag, E.coli - 01-P2113 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

FBLIM1 fusion protein - ag3907 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human FBLIM1, His-tagged - FBLIM1-7602H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human FBLIM1, GST-tagged - FBLIM1-12763H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Filamin Binding LIM Protein 1 (FBLIM1) - RPL514Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Filamin-binding LIM protein 1(FBLIM1) - CSB-YP819890HU CSB-EP819890HU CSB-BP819890HU CSB-MP819890HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBLIM1, 1-373aa, Human, His tag, E.coli - ATGP2113 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

FBLIM1 (transcript variant 1) - TP305764 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FBLIM1 (transcript variant 3) - TP311828 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Migfilin Recombinant Protein Antigen - NBP1-86665PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FBLIM1 Peptide, Human - M34GP05555H from Creative Peptides Category Peptide Source Synthetic. Species Human

FBLIM1, Recombinant Protein - MBS205174 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 20 µg, 100 µg Source E Coli Species Human

Filamin Binding LIM Protein 1, Recombinant Protein - MBS146448 from MyBioSource Category Protein Prices $140.00, $205.00, $1,220.00 Sizes 2 µg, 10 µg, 100 µg Source E Coli

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