Gene Symbol | GLRX3 |
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Entrez Gene | 10539 |
Alt Symbol | GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3 |
Species | Human |
Gene Type | protein-coding |
Description | glutaredoxin 3 |
Other Description | PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2 |
Swissprots | B3KMQ5 B3KMP7 O76003 Q9P1B0 Q96CE0 D3DRG2 Q5JV01 Q9P1B1 |
Accessions | EAW49152 EAW49153 EAW49154 EAW49155 O76003 AA995117 AF118649 AAF28841 AF118652 AAF28844 AJ010841 CAA09375 AK022131 BAG51067 AK225609 BC005289 AAH05289 BC014372 AAH14372 BI256922 BP347054 XM_005252657 XP_005252714 NM_001199868 NP_001186797 NM_006541 NP_006532 |
Function | Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269|PubMed:23615448}. |
Subcellular Location | Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. |
PICOT (P-18) - sc-69309 from Santa Cruz Biotechnology
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PICOT (C-20) - sc-69306 from Santa Cruz Biotechnology
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PICOT (D-10) - sc-390068 from Santa Cruz Biotechnology
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PICOT (E-19) - sc-69308 from Santa Cruz Biotechnology
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PICOT (JF-6) - sc-100601 from Santa Cruz Biotechnology
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Anti-TXNL2 antibody - ab56686 from Abcam
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Anti-TXNL2 antibody - N-terminal - ab170794 from Abcam
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Anti-GLRX3 / Glutaredoxin 3 Antibody - LS-C334368 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117) - LS-C294240 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117) - LS-C314322 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa126-294) - LS-C182864 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (phospho-Ser695) - LS-C183891 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (phospho-Ser676) - LS-C183892 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (phospho-Ser695) - LS-C190860 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, AP) - LS-C272789 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, APC) - LS-C272790 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, FITC) - LS-C272792 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, Biotin) - LS-C272793 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, Azide-free, HRP) - LS-C272794 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, PE) - LS-C272795 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa159-258, Biotin) - LS-C299988 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117, Biotin) - LS-C298589 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (N-Terminus) - LS-C102812 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa159-258, FITC) - LS-C304160 from LifeSpan Bioscience
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Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117, FITC) - LS-C301892 from LifeSpan Bioscience
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