GLRX3

Gene Symbol GLRX3
Entrez Gene 10539
Alt Symbol GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3
Species Human
Gene Type protein-coding
Description glutaredoxin 3
Other Description PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2
Swissprots B3KMQ5 B3KMP7 O76003 Q9P1B0 Q96CE0 D3DRG2 Q5JV01 Q9P1B1
Accessions EAW49152 EAW49153 EAW49154 EAW49155 O76003 AA995117 AF118649 AAF28841 AF118652 AAF28844 AJ010841 CAA09375 AK022131 BAG51067 AK225609 BC005289 AAH05289 BC014372 AAH14372 BI256922 BP347054 XM_005252657 XP_005252714 NM_001199868 NP_001186797 NM_006541 NP_006532
Function Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269|PubMed:23615448}.
Subcellular Location Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

PICOT (P-18) - sc-69309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PICOT (P-18): sc-69309. Western blot analysis of PICOT expression in HeLa whole cell lysate.

PICOT (C-20) - sc-69306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PICOT (D-10) - sc-390068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PICOT (D-10): sc-390068. Western blot analysis of PICOT expression in NTERA-2 cl.D1 (A) and HeLa (B) whole cell lysates and human testis tissue extract (C).

PICOT (E-19) - sc-69308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PICOT (JF-6) - sc-100601 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PICOT (JF-6): sc-100601. Western blot analysis of PICOT expression in HeLa whole cell lysate.

Anti-TXNL2 antibody - ab56686 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TXNL2 antibody - N-terminal - ab170794 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of HepG2 cells using ab170794 at a 1/10 dilution (right/green histogram) compared to a negative control cell (left/blue histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used .

Anti-GLRX3 / Glutaredoxin 3 Antibody - LS-C334368 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using GLRX3 antibody.

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117) - LS-C294240 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant GLRX3 / Glutaredoxin 3.

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117) - LS-C314322 from LifeSpan Bioscience

Prices $415.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant GLRX3 / Glutaredoxin 3.

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa126-294) - LS-C182864 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (phospho-Ser695) - LS-C183891 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (phospho-Ser676) - LS-C183892 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (phospho-Ser695) - LS-C190860 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, AP) - LS-C272789 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, APC) - LS-C272790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, FITC) - LS-C272792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, Biotin) - LS-C272793 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, Azide-free, HRP) - LS-C272794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa88-118, PE) - LS-C272795 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa159-258, Biotin) - LS-C299988 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117, Biotin) - LS-C298589 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (N-Terminus) - LS-C102812 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GLRX3 / TXNL2 antibody LS-C102812 Western blot of HepG2 cell lysate.

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa159-258, FITC) - LS-C304160 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GLRX3 / Glutaredoxin 3 Antibody (aa10-117, FITC) - LS-C301892 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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