| Gene Symbol |
GLRX3
|
| Entrez Gene |
10539
|
| Alt Symbol |
GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutaredoxin 3
|
| Other Description |
PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2
|
| Swissprots |
B3KMQ5 B3KMP7 O76003 Q9P1B0 Q96CE0 D3DRG2 Q5JV01 Q9P1B1
|
| Accessions |
EAW49152 EAW49153 EAW49154 EAW49155 O76003 AA995117 AF118649 AAF28841 AF118652 AAF28844 AJ010841 CAA09375 AK022131 BAG51067 AK225609 BC005289 AAH05289 BC014372 AAH14372 BI256922 BP347054 XM_005252657 XP_005252714 NM_001199868 NP_001186797 NM_006541 NP_006532
|
| Function |
Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269|PubMed:23615448}.
|
| Subcellular Location |
Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
|
![Western Blot: TXNL2 Overexpression Lysate (Adult Normal) [NBL1-11125] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TXNL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7402_TXNL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11125-img0002.jpg)