| Gene Symbol | GLRX3 |
|---|---|
| Entrez Gene | 10539 |
| Alt Symbol | GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutaredoxin 3 |
| Other Description | PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2 |
| Swissprots | B3KMQ5 B3KMP7 O76003 Q9P1B0 Q96CE0 D3DRG2 Q5JV01 Q9P1B1 |
| Accessions | EAW49152 EAW49153 EAW49154 EAW49155 O76003 AA995117 AF118649 AAF28841 AF118652 AAF28844 AJ010841 CAA09375 AK022131 BAG51067 AK225609 BC005289 AAH05289 BC014372 AAH14372 BI256922 BP347054 XM_005252657 XP_005252714 NM_001199868 NP_001186797 NM_006541 NP_006532 |
| Function | Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269|PubMed:23615448}. |
| Subcellular Location | Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. |