Gene Symbol | GLRX3 |
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Entrez Gene | 10539 |
Alt Symbol | GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3 |
Species | Human |
Gene Type | protein-coding |
Description | glutaredoxin 3 |
Other Description | PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2 |
Swissprots | B3KMQ5 B3KMP7 O76003 Q9P1B0 Q96CE0 D3DRG2 Q5JV01 Q9P1B1 |
Accessions | EAW49152 EAW49153 EAW49154 EAW49155 O76003 AA995117 AF118649 AAF28841 AF118652 AAF28844 AJ010841 CAA09375 AK022131 BAG51067 AK225609 BC005289 AAH05289 BC014372 AAH14372 BI256922 BP347054 XM_005252657 XP_005252714 NM_001199868 NP_001186797 NM_006541 NP_006532 |
Function | Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269|PubMed:23615448}. |
Subcellular Location | Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. |
PICOT CRISPR/Cas9 KO Plasmid (h) - sc-417810 from Santa Cruz Biotechnology
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PICOT HDR Plasmid (h) - sc-417810-HDR from Santa Cruz Biotechnology
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PICOT Double Nickase Plasmid (h) - sc-417810-NIC from Santa Cruz Biotechnology
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PICOT Double Nickase Plasmid (h2) - sc-417810-NIC-2 from Santa Cruz Biotechnology
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PICOT CRISPR Activation Plasmid (h) - sc-417810-ACT from Santa Cruz Biotechnology
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PICOT CRISPR Activation Plasmid (h2) - sc-417810-ACT-2 from Santa Cruz Biotechnology
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PICOT Lentiviral Activation Particles (h) - sc-417810-LAC from Santa Cruz Biotechnology
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PICOT Lentiviral Activation Particles (h2) - sc-417810-LAC-2 from Santa Cruz Biotechnology
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PICOT siRNA (h) - sc-76132 from Santa Cruz Biotechnology
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PICOT shRNA Plasmid (h) - sc-76132-SH from Santa Cruz Biotechnology
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PICOT shRNA (h) Lentiviral Particles - sc-76132-V from Santa Cruz Biotechnology
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TXNL2 RNAi - H00010539-R01 from Novus Biologicals
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MISSION® esiRNA - EHU106721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9359 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9359 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02267 from Sigma-Aldrich
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GLRX3 siRNA (Human) - CRH7164 from Cohesion Biosciences
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GLRX3 - MBS8233298 from MyBioSource
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Human GLRX3 siRNA - orb267666 from Biorbyt
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GLRX3 shRNA Plasmid (Human) - CHH7164 from Cohesion Biosciences
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GLRX3 miRNA 3'UTR clone - MiUTR3H-12579 from Creative biogene
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