GLRX3

Gene Symbol GLRX3
Entrez Gene 10539
Alt Symbol GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3
Species Human
Gene Type protein-coding
Description glutaredoxin 3
Other Description PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2
Swissprots B3KMQ5 B3KMP7 O76003 Q9P1B0 Q96CE0 D3DRG2 Q5JV01 Q9P1B1
Accessions EAW49152 EAW49153 EAW49154 EAW49155 O76003 AA995117 AF118649 AAF28841 AF118652 AAF28844 AJ010841 CAA09375 AK022131 BAG51067 AK225609 BC005289 AAH05289 BC014372 AAH14372 BI256922 BP347054 XM_005252657 XP_005252714 NM_001199868 NP_001186797 NM_006541 NP_006532
Function Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269|PubMed:23615448}.
Subcellular Location Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

PICOT CRISPR/Cas9 KO Plasmid (h) - sc-417810 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT HDR Plasmid (h) - sc-417810-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT Double Nickase Plasmid (h) - sc-417810-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT Double Nickase Plasmid (h2) - sc-417810-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT CRISPR Activation Plasmid (h) - sc-417810-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT CRISPR Activation Plasmid (h2) - sc-417810-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT Lentiviral Activation Particles (h) - sc-417810-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT Lentiviral Activation Particles (h2) - sc-417810-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PICOT siRNA (h) - sc-76132 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PICOT shRNA Plasmid (h) - sc-76132-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PICOT shRNA (h) Lentiviral Particles - sc-76132-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TXNL2 RNAi - H00010539-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU106721 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9359 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9359 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02267 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02267

GLRX3 siRNA (Human) - CRH7164 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GLRX3 - MBS8233298 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human GLRX3 siRNA - orb267666 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GLRX3 shRNA Plasmid (Human) - CHH7164 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GLRX3 miRNA 3'UTR clone - MiUTR3H-12579 from Creative biogene

Species Reactivities Human
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