| Gene Symbol |
METAP2
|
| Entrez Gene |
10988
|
| Alt Symbol |
MAP2, MNPEP, p67, p67eIF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methionyl aminopeptidase 2
|
| Other Description |
MAP 2|eIF-2-associated p67 homolog|initiation factor 2-associated 67 kDa glycoprotein|metAP 2|methionine aminopeptidase 2|p67|p67eIF2|peptidase M 2
|
| Swissprots |
Q8NB11 G3XA91 B2RDI8 P50579 B4DUX5
|
| Accessions |
CCO13769 EAW97537 EAW97538 EAW97539 P50579 AK055692 AK091730 BAC03733 AK125296 BAG54178 AK300836 BAG62487 AK315559 BAG37935 BC013782 AAH13782 BC016008 AAH16008 DQ891013 ABM81939 DQ894193 ABM85119 DW409106 U13261 AAC63402 XM_005268583 XP_005268640 NM_006838 NP_006829
|
| Function |
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.
|