METAP2

Gene Symbol METAP2
Entrez Gene 10988
Alt Symbol MAP2, MNPEP, p67, p67eIF2
Species Human
Gene Type protein-coding
Description methionyl aminopeptidase 2
Other Description MAP 2|eIF-2-associated p67 homolog|initiation factor 2-associated 67 kDa glycoprotein|metAP 2|methionine aminopeptidase 2|p67|p67eIF2|peptidase M 2
Swissprots Q8NB11 G3XA91 B2RDI8 P50579 B4DUX5
Accessions CCO13769 EAW97537 EAW97538 EAW97539 P50579 AK055692 AK091730 BAC03733 AK125296 BAG54178 AK300836 BAG62487 AK315559 BAG37935 BC013782 AAH13782 BC016008 AAH16008 DQ891013 ABM81939 DQ894193 ABM85119 DW409106 U13261 AAC63402 XM_005268583 XP_005268640 NM_006838 NP_006829
Function Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.

MetAP2 (D3I1H) Rabbit mAb - 12547 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3I1H
Western blot analysis of extracts from various cell lines using MetAP2 (D3I1H) Rabbit mAb.

MetAP2 Antibody - 11833 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

MetAP-2 (A-9) - sc-365959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MetAP-2 (A-9): sc-365959. Western blot analysis of MetAP-2 expression in non-transfected: sc-117752 (A) and human MetAP-2 transfected: sc-113324 (B) 293T whole cell lysates.

MetAP-2 (B-8) - sc-166827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MetAP-2 (B-8): sc-166827. Western blot analysis of MetAP-2 expression in non-transfected: sc-117752 (A) and human MetAP-2 transfected: sc-113324 (B) 293T whole cell lysates.

MetAP-2 (C-15) - sc-49450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MetAP-2 (C-15): sc-49450. Western blot analysis of MetAP-2 expression in non-transfected: sc-117752 (A) and mouse MetAP-2 transfected: sc-121610 (B) 293T whole cell lysates.

MetAP-2 (D-1) - sc-365204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MetAP-2 (D-1): sc-365204. Western blot analysis of MetAP-2 expression in non-transfected 293T: sc-117752 (A), mouse MetAP-2 transfected 293T: sc-121610 (B) and HeLa (C) whole cell lysates.

MetAP-2 (D-7) - sc-166773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MetAP-2 (D-7): sc-166773. Western blot analysis of MetAP-2 expression in non-transfected: sc-117752 (A) and human MetAP-2 transfected: sc-113324 (B) 293T whole cell lysates.

MetAP-2 (D-20) - sc-49451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MetAP-2 (D-20): sc-49451. Western blot analysis of MetAP-2 expression in non-transfected: sc-117752 (A) and mouse MetAP-2 transfected: sc-121610 (B) 293T whole cell lysates.

MetAP-2 (F-7) - sc-365637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MetAP-2 (F-7): sc-365637. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

MetAP-2 (E-14) - sc-49452 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MetAP-2 (E-14): sc-49452. Western blot analysis of MetAP-2 expression in ECV304 (A), HeLa (B), Caco-2 (C) and HCT 116 (D) whole cell lysates.

MetAP-2 (G-5) - sc-166826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MetAP-2 (G-5): sc-166826. Western blot analysis of MetAP-2 expression in non-transfected: sc-117752 (A) and human MetAP-2 transfected: sc-113324 (B) 293T whole cell lysates.

MetAP-2 (H-300) - sc-67234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MetAP-2 (H-300): sc-67234. Western blot analysis of MetAP-2 expression in non-transfected 293T: sc-117752 (A), human MetAP-2 transfected 293T: sc-113324 (B) and HeLa (C) whole cell lysates.

Anti-Methionine Aminopeptidase 2 antibody [EPR6886(B)] - ab124953 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6886(B)
All lanes : Anti-Methionine Aminopeptidase 2 antibody [EPR6886(B)] (ab124953) at 1/1000 dilutionLane 1 : HepG2 cell lysatesLane 2 : 293T cell lysatesLane 3 : HeLa cell lysatesLane 4 : C6 cell lysatesLane 5 : RAW 264.7 cell lysatesLane 6 : PC12 cell lysatesLane 7 : NIH 3T3 cell lysatesLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Methionine Aminopeptidase 2 antibody [EPR6887] - ab134124 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6887
Overlay histogram showing HeLa cells stained with ab134124 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab134124, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Methionine Aminopeptidase 2 antibody - ab89808 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Methionine Aminopeptidase 2 antibody (ab89808) at 1 µg/ml + Human liver tissue lysate at 50 µg

Anti-Methionine Aminopeptidase 2 antibody - ab123266 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Methionine Aminopeptidase 2 antibody (ab123266) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-METAP2 Antibody (clone 1F6) - LS-C175227 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F6
IHC of paraffin-embedded Human pancreas tissue using anti-METAP2 mouse monoclonal antibody.

Anti-METAP2 Antibody (aa2-478) - LS-C125935 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-METAP2 Antibody (N-Terminus) - LS-C130739 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-METAP2 Antibody (aa33-61, Biotin) - LS-C263056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-METAP2 Antibody (aa33-61, APC) - LS-C263057 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-METAP2 Antibody (aa33-61, AP) - LS-C263055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-METAP2 Antibody (aa33-61, PE) - LS-C263060 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-METAP2 Antibody (aa33-61, FITC) - LS-C263059 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-METAP2 Antibody (aa33-61, Azide-free, HRP) - LS-C263058 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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