METAP2

Gene Symbol	METAP2
Entrez Gene	10988
Alt Symbol	MAP2, MNPEP, p67, p67eIF2
Species	Human
Gene Type	protein-coding
Description	methionyl aminopeptidase 2
Other Description	MAP 2|eIF-2-associated p67 homolog|initiation factor 2-associated 67 kDa glycoprotein|metAP 2|methionine aminopeptidase 2|p67|p67eIF2|peptidase M 2
Swissprots	Q8NB11 G3XA91 B2RDI8 P50579 B4DUX5
Accessions	CCO13769 EAW97537 EAW97538 EAW97539 P50579 AK055692 AK091730 BAC03733 AK125296 BAG54178 AK300836 BAG62487 AK315559 BAG37935 BC013782 AAH13782 BC016008 AAH16008 DQ891013 ABM81939 DQ894193 ABM85119 DW409106 U13261 AAC63402 XM_005268583 XP_005268640 NM_006838 NP_006829
Function	Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® MetAP2 siRNA I - 12149 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

MetAP-2 CRISPR/Cas9 KO Plasmid (h) - sc-402529 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 HDR Plasmid (h) - sc-402529-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 Double Nickase Plasmid (h) - sc-402529-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 Double Nickase Plasmid (h2) - sc-402529-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 CRISPR Activation Plasmid (h) - sc-402529-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 CRISPR Activation Plasmid (h2) - sc-402529-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 Lentiviral Activation Particles (h) - sc-402529-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 Lentiviral Activation Particles (h2) - sc-402529-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MetAP-2 siRNA (h) - sc-61024 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MetAP-2 shRNA Plasmid (h) - sc-61024-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MetAP-2 shRNA (h) Lentiviral Particles - sc-61024-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU073971 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN13218 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13218 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

METAP2 siRNA (Human) - CRH7503 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human METAP2 (NM_006838.3) - SHH340579 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human METAP2(NM_006838.3) - SHH185339 from Creative biogene Category siRNA Species Reactivities Human

Human METAP2 siRNA - orb268005 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

METAP2 shRNA Plasmid (Human) - CHH7503 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

METAP2 miRNA 3'UTR clone - MiUTR1H-06215 from Creative biogene Species Reactivities Human

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