GBP1

Gene Symbol GBP1
Entrez Gene 2633
Alt Symbol -
Species Human
Gene Type protein-coding
Description guanylate binding protein 1, interferon-inducible
Other Description GBP-1|GTP-binding protein 1|guanine nucleotide-binding protein 1|guanylate binding protein 1, interferon-inducible, 67kDa|huGBP-1|interferon-induced guanylate-binding protein 1
Swissprots Q5T8M1 D3DT26 P32455
Accessions EAW73148 EAW73149 EAW73150 P32455 AB208912 BAD92149 AK291783 BAF84472 AK298032 BAG60334 AK303893 BAG64827 AY920436 AAX13805 BC002666 AAH02666 BF058809 BT006847 AAP35493 CB164272 CD676970 DQ890759 ABM81685 DQ893924 ABM84850 M55542 AAA35871 XM_006710573 XP_006710636 NM_002053 NP_002044
Function Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. {ECO:0000269|PubMed:22106366}.
Subcellular Location Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor.

GBP1 (1B1) - sc-53857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
GBP1 (1B1): sc-53857. Western blot analysis of GBP1 expression in HUVEC (A), MCF7 (B,D) and BT-20 (C,E) whole cell lysates under reducing (A,B,C) and non-reducing (D,E) conditions.

GBP1 (N-17) - sc-10579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GBP1-5 (G-12) - sc-166960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GBP1-5 (G-12): sc-166960. Western blot analysis of GBP1-5 expression in HUV-EC-C (A) and BT-20 (B) whole cell lysates.

GBP1-5 (H-300) - sc-28579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GBP1-5 (H-300): sc-28579. Western blot analysis of GBP1-5 expression in mouse uterus tissue extract.

Anti-GBP1 antibody - ab74864 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GBP1 antibody (ab74864) at 1/500 dilutionLane 1 : Extracts from HUVEC cellsLane 2 : Extracts from HUVEC cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-GBP1 antibody - ab153850 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GBP1 antibody (ab153850) at 1/1000 dilutionLane 1 : A431 (30 µg whole cell lysate)Lane 2 : MOLT4 (30 µg whole cell lysate)

Anti-GBP1 antibody - ab88836 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-GBP1 antibody (ab88836) at 1/500 dilution + human colon tissue lysate at 50 µgdeveloped using the ECL technique

Anti-GBP1 antibody - ab113019 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GBP1 antibody (ab113019) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

Anti-GBP1 antibody - ab121039 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GBP1 antibody (ab121039) at 3 µg/mlLane 1 : HCT-116 lysate Lane 2 : HCT-116 lysate with immunizing peptideLane 3 : RAW lysate Lysates/proteins at 40 µg per lane.developed using the ECL technique

Anti-GBP1 antibody [1B2] - ab119236 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B2
All lanes : Anti-GBP1 antibody [1B2] (ab119236) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY GBP1 cDNALysates/proteins at 5 µg per lane.

Anti-GBP1 antibody [4D10] - ab109995 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4D10
Anti-GBP1 antibody [4D10] (ab109995) + Human spleen lysate

Anti-GBP1 antibody [EPR8285] - ab131255 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8285
All lanes : Anti-GBP1 antibody [EPR8285] (ab131255) at 1/1000 dilutionLane 1 : HeLa cell lysate, treated with IFN gamma Lane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti Rabbit IgG at 1/2000 dilution

Anti-GBP1 Antibody (aa500-550) - LS-C148859 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa141-170, APC) - LS-C257591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa141-170, Biotin) - LS-C257592 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa141-170, Azide-free, HRP) - LS-C257594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa141-170, FITC) - LS-C257593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa141-170, PE) - LS-C257595 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa141-170, AP) - LS-C259483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody - LS-C308065 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GBP1 Antibody - LS-C311162 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (aa1-593, Azide-free) - LS-C327501 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-GBP1 Antibody (aa140-170) - LS-C321567 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBP1 Antibody (Glu99) - LS-C177346 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GBP1 (E99) pAb in extracts from HUVEC cells.

Anti-GBP1 Antibody (aa141-170) - LS-C166396 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GBP1 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The GBP1 antibody detected the GBP1 protein (arrow).
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