| Gene Symbol |
GBP1
|
| Entrez Gene |
2633
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanylate binding protein 1, interferon-inducible
|
| Other Description |
GBP-1|GTP-binding protein 1|guanine nucleotide-binding protein 1|guanylate binding protein 1, interferon-inducible, 67kDa|huGBP-1|interferon-induced guanylate-binding protein 1
|
| Swissprots |
Q5T8M1 D3DT26 P32455
|
| Accessions |
EAW73148 EAW73149 EAW73150 P32455 AB208912 BAD92149 AK291783 BAF84472 AK298032 BAG60334 AK303893 BAG64827 AY920436 AAX13805 BC002666 AAH02666 BF058809 BT006847 AAP35493 CB164272 CD676970 DQ890759 ABM81685 DQ893924 ABM84850 M55542 AAA35871 XM_006710573 XP_006710636 NM_002053 NP_002044
|
| Function |
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. {ECO:0000269|PubMed:22106366}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor.
|