| Gene Symbol |
NOXO1
|
| Entrez Gene |
124056
|
| Alt Symbol |
P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NADPH oxidase organizer 1
|
| Other Description |
NADPH oxidase regulatory protein|Nox organizer 1|SH3 and PX domain-containing protein 5|nox-organizing protein 1|regulatory protein P41NOX
|
| Swissprots |
Q8NFA2 Q86YM1 Q8NFA3 Q96B73
|
| Accessions |
EAW85581 EAW85582 EAW85583 EAW85584 Q8NFA2 AB097667 BAC76711 AF532983 AAM97925 AF532984 AAM97926 AF532985 AAM97927 AF539796 AAN75141 AK292197 BAF84886 AK310198 AK313917 AY191359 AAO38665 AY255768 AAP13479 BC015917 AAH15917 DB009385 XM_005255099 XP_005255156 NM_001267721 NP_001254650 NM_144603 NP_653204 NM_172167 NP_751907 NM_172168 NP_751908
|
| Function |
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}.
|
| Subcellular Location |
Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
|
| Tissue Specificity |
Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15949904}.
|