NOXO1

Gene Symbol NOXO1
Entrez Gene 124056
Alt Symbol P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28
Species Human
Gene Type protein-coding
Description NADPH oxidase organizer 1
Other Description NADPH oxidase regulatory protein|Nox organizer 1|SH3 and PX domain-containing protein 5|nox-organizing protein 1|regulatory protein P41NOX
Swissprots Q8NFA2 Q86YM1 Q8NFA3 Q96B73
Accessions EAW85581 EAW85582 EAW85583 EAW85584 Q8NFA2 AB097667 BAC76711 AF532983 AAM97925 AF532984 AAM97926 AF532985 AAM97927 AF539796 AAN75141 AK292197 BAF84886 AK310198 AK313917 AY191359 AAO38665 AY255768 AAP13479 BC015917 AAH15917 DB009385 XM_005255099 XP_005255156 NM_001267721 NP_001254650 NM_144603 NP_653204 NM_172167 NP_751907 NM_172168 NP_751908
Function Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}.
Subcellular Location Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
Tissue Specificity Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15949904}.

NOXO1 CRISPR/Cas9 KO Plasmid (h) - sc-410273 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 HDR Plasmid (h) - sc-410273-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 Double Nickase Plasmid (h) - sc-410273-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 Double Nickase Plasmid (h2) - sc-410273-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 CRISPR Activation Plasmid (h) - sc-410273-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 CRISPR Activation Plasmid (h2) - sc-410273-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 Lentiviral Activation Particles (h) - sc-410273-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 Lentiviral Activation Particles (h2) - sc-410273-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXO1 siRNA (h) - sc-75949 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOXO1 shRNA Plasmid (h) - sc-75949-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOXO1 shRNA (h) Lentiviral Particles - sc-75949-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOXO1 RNAi - H00124056-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NOXO1 RNAi - H00124056-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NOXO1 RNAi - H00124056-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU152701 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15433 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15433 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NOXO1 siRNA (Human) - CRJ4751 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NOXO1 (NM_172168.2) - SHH353976 from Creative biogene

Category siRNA
Species Reactivities Human

NOXO1 shRNA Plasmid (Human) - CHJ4751 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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