NOXO1

Gene Symbol	NOXO1
Entrez Gene	124056
Alt Symbol	P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28
Species	Human
Gene Type	protein-coding
Description	NADPH oxidase organizer 1
Other Description	NADPH oxidase regulatory protein|Nox organizer 1|SH3 and PX domain-containing protein 5|nox-organizing protein 1|regulatory protein P41NOX
Swissprots	Q8NFA2 Q86YM1 Q8NFA3 Q96B73
Accessions	EAW85581 EAW85582 EAW85583 EAW85584 Q8NFA2 AB097667 BAC76711 AF532983 AAM97925 AF532984 AAM97926 AF532985 AAM97927 AF539796 AAN75141 AK292197 BAF84886 AK310198 AK313917 AY191359 AAO38665 AY255768 AAP13479 BC015917 AAH15917 DB009385 XM_005255099 XP_005255156 NM_001267721 NP_001254650 NM_144603 NP_653204 NM_172167 NP_751907 NM_172168 NP_751908
Function	Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}.
Subcellular Location	Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
Tissue Specificity	Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15949904}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

NOXO1 overexpression lysate - LY403398 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NOXO1 293 Cell Lysate - 402944 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

NOXO1 293 Cell Lysate - 404024 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

NOXO1 Overexpression Lysate (Native) - NBL1-13735 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NOXO1 Overexpression Lysate (Native) - NBL1-13736 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NOXO1 Over-expression Lysate Product - GWB-C0AED9 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

NOXO1 Over-expression Lysate Product - GWB-5D71A7 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human NOXO1 Knockdown Stable Cell Line - CSC-DC010529 from Creative biogene Category Cell Line Species Human

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