MAGED1

Gene Symbol MAGED1
Entrez Gene 9500
Alt Symbol DLXIN-1, NRAGE
Species Human
Gene Type protein-coding
Description melanoma antigen family D1
Other Description MAGE tumor antigen CCF|MAGE-D1 antigen|melanoma antigen family D, 1|melanoma-associated antigen D1|neurotrophin receptor-interacting MAGE homolog
Swissprots Q8WY92 Q8IZ84 Q9H352 Q5VSH6 Q9HBT4 Q9UF36 Q9Y5V3
Accessions EAW62896 EAW62897 Q9Y5V3 AF124440 AAD31421 AF132205 AAG35551 AF217963 AAG09704 AF258554 AAG23757 AF300328 AAQ14483 AK074092 BAB84918 AK298574 BAG60766 AK308706 AK314053 AL133628 CAB63752 BC014070 AAH14070 BC032473 AAH32473 BF529661 BG819042 BX422007 CD387872 XM_011530835 XP_011529137 NM_001005332 NP_001005332 NM_001005333 NP_001005333 NM_006986 NP_008917
Function Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
Tissue Specificity Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Top Pathways Neurotrophin signaling pathway

NRAGE (31) - sc-136552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAGE (31): sc-136552. Western blot analysis of NRAGE expression in WI 38 (A), PC-12 (B), Jurkat (C) and L6 (D) whole cell lysates.

NRAGE (48) - sc-136450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAGE (48): sc-136450. Western blot analysis of NRAGE expression in SW13 whole cell lysate.

NRAGE (F-9) - sc-393291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAGE (F-9): sc-393291. Western blot analysis of NRAGE expression in non-transfected: sc-117752 (A) and mouse NRAGE transfected: sc-122121 (B) 293T whole cell lysates.

NRAGE (H-7) - sc-398493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAGE (H-7): sc-398493. Western blot analysis of NRAGE expression in non-transfected: sc-117752 (A) and mouse NRAGE transfected: sc-122121 (B) 293T whole cell lysates.

NRAGE (C-20) - sc-14400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NRAGE (H-300) - sc-28243 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NRAGE (H-300): sc-28243. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

NRAGE (T-20) - sc-14398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NRAGE (T-20): sc-14398. Western blot analysis of NRAGE expression in non-transfected: sc-117752 (A) and human NRAGE transfected: sc-114826 (B) 293T whole cell lysates.

NRAGE (AK47) - sc-130434 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NRAGE (AK47): sc-130434. Western blot analysis of NRAGE expression in Jurkat whole cell lysate.

Anti-MAGED1 antibody - ab38492 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MAGED1 antibody (ab38492) at 1/100 dilution + A549 lysate

Anti-MAGED1 antibody - ab77045 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-MAGED1 antibody (ab77045) at 1/500 dilution + Jurkat cell lysate at 25 µgSecondaryHRP-conjugated goat anti-mouse IgG at 1/2500 dilutiondeveloped using the ECL technique

Anti-MAGED1 antibody - ab172368 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MAGED1 antibody (ab172368) at 1 µg/mlLane 1 : MAGED1 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-MAGED1 antibody [MM0846-23C26] - ab201640 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0846-23C26

Anti-MAGED1 antibody - N-terminal - ab180841 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAGED1 antibody - N-terminal (ab180841) at 1/500 dilution + A549 cell lysate

Anti-MAGED1 / NRAGE Antibody (aa441-456) - LS-C3091 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (aa53-295) - LS-C8662 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (Internal, AP) - LS-C279061 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (aa73-254) - LS-C125905 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (Internal, APC) - LS-C279063 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (Internal, FITC) - LS-C279064 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (Internal, Azide-free, HRP) - LS-C279066 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (Internal, Biotin) - LS-C279065 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (aa516-565) - LS-C151638 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAGED1 / NRAGE antibody Western Blot of Jurkat.

Anti-MAGED1 / NRAGE Antibody (Internal, PE) - LS-C279067 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody - LS-C311357 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAGED1 / NRAGE Antibody (Internal) - LS-C330516 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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