| Gene Symbol |
MAGED1
|
| Entrez Gene |
9500
|
| Alt Symbol |
DLXIN-1, NRAGE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
melanoma antigen family D1
|
| Other Description |
MAGE tumor antigen CCF|MAGE-D1 antigen|melanoma antigen family D, 1|melanoma-associated antigen D1|neurotrophin receptor-interacting MAGE homolog
|
| Swissprots |
Q8WY92 Q8IZ84 Q9H352 Q5VSH6 Q9HBT4 Q9UF36 Q9Y5V3
|
| Accessions |
EAW62896 EAW62897 Q9Y5V3 AF124440 AAD31421 AF132205 AAG35551 AF217963 AAG09704 AF258554 AAG23757 AF300328 AAQ14483 AK074092 BAB84918 AK298574 BAG60766 AK308706 AK314053 AL133628 CAB63752 BC014070 AAH14070 BC032473 AAH32473 BF529661 BG819042 BX422007 CD387872 XM_011530835 XP_011529137 NM_001005332 NP_001005332 NM_001005333 NP_001005333 NM_006986 NP_008917
|
| Function |
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
|
| Top Pathways |
Neurotrophin signaling pathway
|
![Western Blot: MAGED1 Overexpression Lysate (Adult Normal) [NBP2-07545] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAGED1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2906_MAGED1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07545-img0001.jpg)