MAGED1

Gene Symbol MAGED1
Entrez Gene 9500
Alt Symbol DLXIN-1, NRAGE
Species Human
Gene Type protein-coding
Description melanoma antigen family D1
Other Description MAGE tumor antigen CCF|MAGE-D1 antigen|melanoma antigen family D, 1|melanoma-associated antigen D1|neurotrophin receptor-interacting MAGE homolog
Swissprots Q8WY92 Q8IZ84 Q9H352 Q5VSH6 Q9HBT4 Q9UF36 Q9Y5V3
Accessions EAW62896 EAW62897 Q9Y5V3 AF124440 AAD31421 AF132205 AAG35551 AF217963 AAG09704 AF258554 AAG23757 AF300328 AAQ14483 AK074092 BAB84918 AK298574 BAG60766 AK308706 AK314053 AL133628 CAB63752 BC014070 AAH14070 BC032473 AAH32473 BF529661 BG819042 BX422007 CD387872 XM_011530835 XP_011529137 NM_001005332 NP_001005332 NM_001005333 NP_001005333 NM_006986 NP_008917
Function Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
Tissue Specificity Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Top Pathways Neurotrophin signaling pathway

NRAGE CRISPR/Cas9 KO Plasmid (h) - sc-405039 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE HDR Plasmid (h) - sc-405039-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE Double Nickase Plasmid (h) - sc-405039-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE Double Nickase Plasmid (h2) - sc-405039-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE CRISPR Activation Plasmid (h) - sc-405039-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE CRISPR Activation Plasmid (h2) - sc-405039-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE Lentiviral Activation Particles (h) - sc-405039-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE Lentiviral Activation Particles (h2) - sc-405039-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRAGE siRNA (h) - sc-37320 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NRAGE shRNA Plasmid (h) - sc-37320-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NRAGE shRNA (h) Lentiviral Particles - sc-37320-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NRAGE/MAGED1 RNAi - H00009500-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU060111 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU118141 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12932 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12932 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01988 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01988

MAGED1 siRNA (Human) - CRH6309 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NRAGE/MAGED1 RNAi - H00009500-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NRAGE/MAGED1 RNAi - H00009500-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MAGED1 (NM_006986.3) - SHH336919 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAGED1(NM_006986.3) - SHH171173 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAGED1(NM_001005332.1) - SHH171191 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAGED1(NM_001005333.1) - SHH171227 from Creative biogene

Category siRNA
Species Reactivities Human

Human MAGED1 siRNA - orb266811 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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