Gene Symbol | MAGED1 |
---|---|
Entrez Gene | 9500 |
Alt Symbol | DLXIN-1, NRAGE |
Species | Human |
Gene Type | protein-coding |
Description | melanoma antigen family D1 |
Other Description | MAGE tumor antigen CCF|MAGE-D1 antigen|melanoma antigen family D, 1|melanoma-associated antigen D1|neurotrophin receptor-interacting MAGE homolog |
Swissprots | Q8WY92 Q8IZ84 Q9H352 Q5VSH6 Q9HBT4 Q9UF36 Q9Y5V3 |
Accessions | EAW62896 EAW62897 Q9Y5V3 AF124440 AAD31421 AF132205 AAG35551 AF217963 AAG09704 AF258554 AAG23757 AF300328 AAQ14483 AK074092 BAB84918 AK298574 BAG60766 AK308706 AK314053 AL133628 CAB63752 BC014070 AAH14070 BC032473 AAH32473 BF529661 BG819042 BX422007 CD387872 XM_011530835 XP_011529137 NM_001005332 NP_001005332 NM_001005333 NP_001005333 NM_006986 NP_008917 |
Function | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}. |
Tissue Specificity | Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. |
Top Pathways | Neurotrophin signaling pathway |
NRAGE CRISPR/Cas9 KO Plasmid (h) - sc-405039 from Santa Cruz Biotechnology
|
||||||||
NRAGE HDR Plasmid (h) - sc-405039-HDR from Santa Cruz Biotechnology
|
||||||||
NRAGE Double Nickase Plasmid (h) - sc-405039-NIC from Santa Cruz Biotechnology
|
||||||||
NRAGE Double Nickase Plasmid (h2) - sc-405039-NIC-2 from Santa Cruz Biotechnology
|
||||||||
NRAGE CRISPR Activation Plasmid (h) - sc-405039-ACT from Santa Cruz Biotechnology
|
||||||||
NRAGE CRISPR Activation Plasmid (h2) - sc-405039-ACT-2 from Santa Cruz Biotechnology
|
||||||||
NRAGE Lentiviral Activation Particles (h) - sc-405039-LAC from Santa Cruz Biotechnology
|
||||||||
NRAGE Lentiviral Activation Particles (h2) - sc-405039-LAC-2 from Santa Cruz Biotechnology
|
||||||||
NRAGE siRNA (h) - sc-37320 from Santa Cruz Biotechnology
|
||||||||
NRAGE shRNA Plasmid (h) - sc-37320-SH from Santa Cruz Biotechnology
|
||||||||
NRAGE shRNA (h) Lentiviral Particles - sc-37320-V from Santa Cruz Biotechnology
|
||||||||
NRAGE/MAGED1 RNAi - H00009500-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU060111 from Sigma-Aldrich
|
||||||||
MISSION® esiRNA - EHU118141 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12932 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12932 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR01988 from Sigma-Aldrich
|
||||||||
MAGED1 siRNA (Human) - CRH6309 from Cohesion Biosciences
|
||||||||
NRAGE/MAGED1 RNAi - H00009500-R03 from Novus Biologicals
|
||||||||
NRAGE/MAGED1 RNAi - H00009500-R02 from Novus Biologicals
|
||||||||
shRNA set against Human MAGED1 (NM_006986.3) - SHH336919 from Creative biogene
|
||||||||
shRNA set against Human MAGED1(NM_006986.3) - SHH171173 from Creative biogene
|
||||||||
shRNA set against Human MAGED1(NM_001005332.1) - SHH171191 from Creative biogene
|
||||||||
shRNA set against Human MAGED1(NM_001005333.1) - SHH171227 from Creative biogene
|
||||||||
Human MAGED1 siRNA - orb266811 from Biorbyt
|