MAGED1

Gene Symbol	MAGED1
Entrez Gene	9500
Alt Symbol	DLXIN-1, NRAGE
Species	Human
Gene Type	protein-coding
Description	melanoma antigen family D1
Other Description	MAGE tumor antigen CCF|MAGE-D1 antigen|melanoma antigen family D, 1|melanoma-associated antigen D1|neurotrophin receptor-interacting MAGE homolog
Swissprots	Q8WY92 Q8IZ84 Q9H352 Q5VSH6 Q9HBT4 Q9UF36 Q9Y5V3
Accessions	EAW62896 EAW62897 Q9Y5V3 AF124440 AAD31421 AF132205 AAG35551 AF217963 AAG09704 AF258554 AAG23757 AF300328 AAQ14483 AK074092 BAB84918 AK298574 BAG60766 AK308706 AK314053 AL133628 CAB63752 BC014070 AAH14070 BC032473 AAH32473 BF529661 BG819042 BX422007 CD387872 XM_011530835 XP_011529137 NM_001005332 NP_001005332 NM_001005333 NP_001005333 NM_006986 NP_008917
Function	Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
Tissue Specificity	Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Top Pathways	Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAGED1 full length protein - ab160515 from Abcam Category Protein Source Wheat germ Species Human

Human MAGED1 full length protein - ab160516 from Abcam Category Protein Source Wheat germ Species Human

Human MAGED1 protein fragment - ab160517 from Abcam Category Protein Source Wheat germ Species Human

Human MAGED1 protein fragment - ab174430 from Abcam Category Protein Source E. coli Species Human

MAGED1 / NRAGE Antibody Blocking Peptide - LS-E8111 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAGED1 / NRAGE Antibody Blocking Peptide - LS-E23392 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NRAGE/MAGED1 Recombinant Protein - H00009500-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

NRAGE/MAGED1 Partial Recombinant Protein - H00009500-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NRAGE/MAGED1 Protein - NBP2-23226 from Novus Biologicals Category Protein Prices $269.00 Sizes 10 µg Source E.coli Species Human

NRAGE/MAGED1 Peptide - P1784 from Novus Biologicals Category Peptide Species Human

MAGED1-Antibody-Center-Blocking-Peptide - BP6176a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAGED1 protein (His tag) - 80R-3588 from Fitzgerald Category Protein Prices $275.00 Sizes 10 µg Source E.coli

MAGE-D1 (504-760, His-tag) - AR51275PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

MAGE-D1 (504-760, His-tag) - AR51275PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

MAGE-D1 - H00009500-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

MAGE-D1 - H00009500-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

MAGE-D1 - H00009500-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

MAGE-D1 - H00009500-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MAGE-D1 - H00009500-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAGE-D1 - H00009500-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAGED1, 504-760aa, Human, His tag, E.coli - 01-P2455 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

MAGED1 fusion protein - ag2109 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MAGED1 fusion protein - Ag17047 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MAGED1 fusion protein - ag17465 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant human MAGED1, His-tagged - MAGED1-2455H from Creative Biomart Category Protein Source E.coli Species Human

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