| Gene Symbol |
SETD8
|
| Entrez Gene |
387893
|
| Alt Symbol |
KMT5A, PR-Set7, SET07, SET8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET domain containing (lysine methyltransferase) 8
|
| Other Description |
H4-K20-HMTase SETD8|H4-K20-specific histone methyltransferase|H4K20-specific histone methyltransferase splice variant Set8b|N-lysine methyltransferase SETD8|PR/SET domain containing protein 8|PR/SET domain-containing protein 07|PR/SET07|SET domain-containing protein 8|histone-lysine N-methyltransferase SETD8|lysine N-methyltransferase 5A
|
| Swissprots |
Q86W83 Q9NQR1 A8K9D0 Q8TD09
|
| Accessions |
EAW98406 EAW98407 EAW98408 EAW98409 Q9NQR1 AF287261 AAF97812 AK292645 BAF85334 AY064546 AAL40879 AY102937 AAM47033 BC050346 AAH50346 BQ773996 HQ259683 ADP08984 HQ448034 ADQ32515 XM_006719394 XP_006719457 XM_011538332 XP_011536634 XM_011538333 XP_011536635 XR_944546 NM_020382 NP_065115
|
| Function |
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12121615, ECO:0000269|PubMed:15200950, ECO:0000269|PubMed:15933069, ECO:0000269|PubMed:15933070, ECO:0000269|PubMed:16517599, EC
|
| Subcellular Location |
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
|
| Top Pathways |
Lysine degradation
|