SETD8

Gene Symbol	SETD8
Entrez Gene	387893
Alt Symbol	KMT5A, PR-Set7, SET07, SET8
Species	Human
Gene Type	protein-coding
Description	SET domain containing (lysine methyltransferase) 8
Other Description	H4-K20-HMTase SETD8|H4-K20-specific histone methyltransferase|H4K20-specific histone methyltransferase splice variant Set8b|N-lysine methyltransferase SETD8|PR/SET domain containing protein 8|PR/SET domain-containing protein 07|PR/SET07|SET domain-containing protein 8|histone-lysine N-methyltransferase SETD8|lysine N-methyltransferase 5A
Swissprots	Q86W83 Q9NQR1 A8K9D0 Q8TD09
Accessions	EAW98406 EAW98407 EAW98408 EAW98409 Q9NQR1 AF287261 AAF97812 AK292645 BAF85334 AY064546 AAL40879 AY102937 AAM47033 BC050346 AAH50346 BQ773996 HQ259683 ADP08984 HQ448034 ADQ32515 XM_006719394 XP_006719457 XM_011538332 XP_011536634 XM_011538333 XP_011536635 XR_944546 NM_020382 NP_065115
Function	Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12121615, ECO:0000269|PubMed:15200950, ECO:0000269|PubMed:15933069, ECO:0000269|PubMed:15933070, ECO:0000269|PubMed:16517599, EC
Subcellular Location	Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KMT5A / SETD8 / Pr-SET7 protein fragment - ab196432 from Abcam Category Protein Prices $858.00 Sizes 50 µg Source E. coli Species Human

KMT5A / SETD8 / Pr-SET7 peptide - ab24159 from Abcam Category Peptide

SETD8 / SET8 Antibody Blocking Peptide - LS-E1300 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETD8 / SET8 Antibody Blocking Peptide - LS-E1299 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETD8 / SET8 Antibody Blocking Peptide - LS-E8285 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETD8 Peptide - P0253 from Novus Biologicals Category Peptide Species Human

SETD8 Peptide - P0252 from Novus Biologicals Category Peptide Species Human

SET07-Antibody-C-term-Blocking-Peptide - BP1191b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SET07-Antibody-N-term-Blocking-Peptide - BP1191a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETD8-Antibody-Center-Blocking-Peptide - BP6557c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SETD8 protein - orb83830 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

SETD8 fusion protein - Ag14478 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SETD8 fusion protein - ag5114 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant SET8 protein - 31321 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant SET8 D338A protein - 31322 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant Human SET Domain Containing (lysine methyltransferase) 8, GST-tagged - SETD8-1631H from Creative Biomart Category Protein Species Human

Recombinant Human SETD8, GST-tagged - SETD8-461H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human SETD8, None tagged - SETD8-886H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human SETD8, GST-tagged - SETD8-6964H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human SETD8, His-tagged - SETD8-2608H from Creative Biomart Category Protein Source E.coli Species Human

Human SETD8 / PR-Set7 Protein - 11726-HNCE-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 100 µg Source E. coli Species Human

Recombinant Human N-lysine methyltransferase SETD8(SETD8) - CSB-YP889082HU CSB-EP889082HU CSB-BP889082HU CSB-MP889082HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant SETD8 protein - 31427 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

SETD8 / SET07 (full length, N-term HIS tag) - TP760171 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human SETD8 / PR-Set7 Protein - PKSH031024 from Elabscience Category Protein Source E. coli Species Human

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