SETD8

Gene Symbol	SETD8
Entrez Gene	387893
Alt Symbol	KMT5A, PR-Set7, SET07, SET8
Species	Human
Gene Type	protein-coding
Description	SET domain containing (lysine methyltransferase) 8
Other Description	H4-K20-HMTase SETD8|H4-K20-specific histone methyltransferase|H4K20-specific histone methyltransferase splice variant Set8b|N-lysine methyltransferase SETD8|PR/SET domain containing protein 8|PR/SET domain-containing protein 07|PR/SET07|SET domain-containing protein 8|histone-lysine N-methyltransferase SETD8|lysine N-methyltransferase 5A
Swissprots	Q86W83 Q9NQR1 A8K9D0 Q8TD09
Accessions	EAW98406 EAW98407 EAW98408 EAW98409 Q9NQR1 AF287261 AAF97812 AK292645 BAF85334 AY064546 AAL40879 AY102937 AAM47033 BC050346 AAH50346 BQ773996 HQ259683 ADP08984 HQ448034 ADQ32515 XM_006719394 XP_006719457 XM_011538332 XP_011536634 XM_011538333 XP_011536635 XR_944546 NM_020382 NP_065115
Function	Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12121615, ECO:0000269|PubMed:15200950, ECO:0000269|PubMed:15933069, ECO:0000269|PubMed:15933070, ECO:0000269|PubMed:16517599, EC
Subcellular Location	Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SET8 siRNA I - 13067 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® SET8 siRNA II - 13107 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Pr-Set7 CRISPR/Cas9 KO Plasmid (h) - sc-415759 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 HDR Plasmid (h) - sc-415759-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 Double Nickase Plasmid (h) - sc-415759-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 Double Nickase Plasmid (h2) - sc-415759-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 CRISPR Activation Plasmid (h) - sc-415759-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 CRISPR Activation Plasmid (h2) - sc-415759-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 Lentiviral Activation Particles (h) - sc-415759-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 Lentiviral Activation Particles (h2) - sc-415759-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 siRNA (h) - sc-62852 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Pr-Set7 shRNA Plasmid (h) - sc-62852-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Pr-Set7 shRNA (h) Lentiviral Particles - sc-62852-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU111111 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19173 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19173 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SETD8 siRNA (Human) - CRJ7768 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SETD8 - MBS828106 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Pr-Set7 CRISPR/Cas9 KO Plasmid (h2) - sc-415759-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Pr-Set7 HDR Plasmid (h2) - sc-415759-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human SETD8 (NM_020382.3) - SHH405656 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SETD8(NM_020382.3) - SHR218616 from Creative biogene Category siRNA Species Reactivities Human

SETD8 shRNA Plasmid (Human) - CHJ7768 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SETD8 miRNA 3'UTR clone - MiUTR1H-09316 from Creative biogene Species Reactivities Human

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