SETD8

Gene Symbol SETD8
Entrez Gene 387893
Alt Symbol KMT5A, PR-Set7, SET07, SET8
Species Human
Gene Type protein-coding
Description SET domain containing (lysine methyltransferase) 8
Other Description H4-K20-HMTase SETD8|H4-K20-specific histone methyltransferase|H4K20-specific histone methyltransferase splice variant Set8b|N-lysine methyltransferase SETD8|PR/SET domain containing protein 8|PR/SET domain-containing protein 07|PR/SET07|SET domain-containing protein 8|histone-lysine N-methyltransferase SETD8|lysine N-methyltransferase 5A
Swissprots Q86W83 Q9NQR1 A8K9D0 Q8TD09
Accessions EAW98406 EAW98407 EAW98408 EAW98409 Q9NQR1 AF287261 AAF97812 AK292645 BAF85334 AY064546 AAL40879 AY102937 AAM47033 BC050346 AAH50346 BQ773996 HQ259683 ADP08984 HQ448034 ADQ32515 XM_006719394 XP_006719457 XM_011538332 XP_011536634 XM_011538333 XP_011536635 XR_944546 NM_020382 NP_065115
Function Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12121615, ECO:0000269|PubMed:15200950, ECO:0000269|PubMed:15933069, ECO:0000269|PubMed:15933070, ECO:0000269|PubMed:16517599, EC
Subcellular Location Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Top Pathways Lysine degradation

SETD8-Over-expression-Lysate - LY11736a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SETD8 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SETD8 gene

SETD8 overexpression lysate - LY402778 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SETD8 293 Cell Lysate - 402417 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

SETD8 Overexpression Lysate (Native) - NBL1-15870 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SETD8 Overexpression Lysate (Adult Normal) [NBL1-15870] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SETD8.

SETD8 Over-expression Lysate Product - GWB-4BAFF3 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human SETD8 Knockdown Stable Cell Line - CSC-DC014085 from Creative biogene

Category Cell Line
Species Human
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