USP2

Gene Symbol	USP2
Entrez Gene	9099
Alt Symbol	UBP41, USP9
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 2
Other Description	41 kDa ubiquitin-specific protease|deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 2|ubiquitin specific protease 12|ubiquitin specific protease 9|ubiquitin thioesterase 2|ubiquitin-specific-processing protease 2
Swissprots	Q96MB9 Q8IW04 B0YJB8 Q8IUM2 Q9BQ21 E9PPM2 O75604
Accessions	ACA06096 ACA06097 EAW67484 EAW67485 EAW67486 O75604 AF079564 AAC28392 AF440755 AAN65363 AI806430 AK057225 BAB71388 AK292255 BAF84944 AK301805 BAH13558 AK309582 BC002854 AAH02854 BC002955 AAH02955 BC041366 AAH41366 DB065104 DB088349 DB098786 DQ892532 ABM83458 DQ895743 ABM86669 XM_005271721 XP_005271778 XM_005271722 XP_005271779 NM_001243759 NP_001230688 NM_004205 NP_004196 NM_171997 NP_741994
Function	Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By simil
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}.
Tissue Specificity	Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). {ECO:0000269|PubMed:20403044}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP2 Antibody - 8036 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

USP2 (C-20) - sc-79300 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

USP2 (E-19) - sc-79301 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

USP2 (H-50) - sc-135282 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

USP2 (P-20) - sc-79302 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-USP2 antibody - ab66556 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP2 antibody - ab101609 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-USP2 antibody - ab168945 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-USP2 antibody - ab62047 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-USP2 antibody - Aminoterminal end - ab71796 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody - LS-C84166 from LifeSpan Bioscience Prices $385.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (AP) - LS-C84219 from LifeSpan Bioscience Prices $755.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody - LS-C87138 from LifeSpan Bioscience Prices $755.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (aa19-49, APC) - LS-C218379 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (aa19-49, Biotin) - LS-C218380 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (aa19-49, FITC) - LS-C218381 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (aa19-49, Azide-free, HRP) - LS-C218382 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (aa19-49, PE) - LS-C218383 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, APC) - LS-C221047 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, FITC) - LS-C221049 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, Biotin) - LS-C221048 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, Azide-free, HRP) - LS-C221050 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, PE) - LS-C221051 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, APC) - LS-C221052 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP2 Antibody (C-Terminus, Biotin) - LS-C221053 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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