USP2

Gene Symbol USP2
Entrez Gene 9099
Alt Symbol UBP41, USP9
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 2
Other Description 41 kDa ubiquitin-specific protease|deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 2|ubiquitin specific protease 12|ubiquitin specific protease 9|ubiquitin thioesterase 2|ubiquitin-specific-processing protease 2
Swissprots Q96MB9 Q8IW04 B0YJB8 Q8IUM2 Q9BQ21 E9PPM2 O75604
Accessions ACA06096 ACA06097 EAW67484 EAW67485 EAW67486 O75604 AF079564 AAC28392 AF440755 AAN65363 AI806430 AK057225 BAB71388 AK292255 BAF84944 AK301805 BAH13558 AK309582 BC002854 AAH02854 BC002955 AAH02955 BC041366 AAH41366 DB065104 DB088349 DB098786 DQ892532 ABM83458 DQ895743 ABM86669 XM_005271721 XP_005271778 XM_005271722 XP_005271779 NM_001243759 NP_001230688 NM_004205 NP_004196 NM_171997 NP_741994
Function Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By simil
Subcellular Location Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}.
Tissue Specificity Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). {ECO:0000269|PubMed:20403044}.

Human-USP2-cDNA-Clone - DC01146 from Abgent, a WuXi AppTec company

Prices $816.75
Sizes 10 µg
Species Human
Accession BC002854

USP2 - MBS1275326 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC002854

human USP2 ORF clone - CDCH098656 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098657 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098658 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098659 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098660 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098661 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098662 from Creative Biomart

Species Human
Accession NM_001243759

human USP2 ORF clone - CDCH098663 from Creative Biomart

Species Human
Accession NM_001243759

Human USP2 ORF Clone(NM_001243759.1) - CDCL180671 from Creative Biomart

Species Human
Accession NM_001243759.1

Human USP2 ORF Clone(NM_001243759.1) - CDCL180672 from Creative Biomart

Species Human
Accession NM_001243759.1

Human USP2 ORF Clone(NM_001243759.1) - CDCL180673 from Creative Biomart

Species Human
Accession NM_001243759.1

human USP2 ORF clone (NM_171997.2) - CDCH098657 from Creative biogene

Species Human

Human USP2 ORF Clone (BC002854) - CDCS409876 from Creative biogene

Species Human
Accession O75604
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