| Gene Symbol | USP2 |
|---|---|
| Entrez Gene | 9099 |
| Alt Symbol | UBP41, USP9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 2 |
| Other Description | 41 kDa ubiquitin-specific protease|deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 2|ubiquitin specific protease 12|ubiquitin specific protease 9|ubiquitin thioesterase 2|ubiquitin-specific-processing protease 2 |
| Swissprots | Q96MB9 Q8IW04 B0YJB8 Q8IUM2 Q9BQ21 E9PPM2 O75604 |
| Accessions | ACA06096 ACA06097 EAW67484 EAW67485 EAW67486 O75604 AF079564 AAC28392 AF440755 AAN65363 AI806430 AK057225 BAB71388 AK292255 BAF84944 AK301805 BAH13558 AK309582 BC002854 AAH02854 BC002955 AAH02955 BC041366 AAH41366 DB065104 DB088349 DB098786 DQ892532 ABM83458 DQ895743 ABM86669 XM_005271721 XP_005271778 XM_005271722 XP_005271779 NM_001243759 NP_001230688 NM_004205 NP_004196 NM_171997 NP_741994 |
| Function | Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By simil |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}. |
| Tissue Specificity | Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). {ECO:0000269|PubMed:20403044}. |
USP2 CRISPR/Cas9 KO Plasmid (h) - sc-411243 from Santa Cruz Biotechnology
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USP2 HDR Plasmid (h) - sc-411243-HDR from Santa Cruz Biotechnology
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USP2 Double Nickase Plasmid (h) - sc-411243-NIC from Santa Cruz Biotechnology
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USP2 Double Nickase Plasmid (h2) - sc-411243-NIC-2 from Santa Cruz Biotechnology
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USP2 CRISPR Activation Plasmid (h) - sc-411243-ACT from Santa Cruz Biotechnology
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USP2 CRISPR Activation Plasmid (h2) - sc-411243-ACT-2 from Santa Cruz Biotechnology
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USP2 Lentiviral Activation Particles (h) - sc-411243-LAC from Santa Cruz Biotechnology
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USP2 Lentiviral Activation Particles (h2) - sc-411243-LAC-2 from Santa Cruz Biotechnology
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USP2 siRNA (h) - sc-76821 from Santa Cruz Biotechnology
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USP2 shRNA Plasmid (h) - sc-76821-SH from Santa Cruz Biotechnology
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USP2 shRNA (h) Lentiviral Particles - sc-76821-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22568 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22568 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05242 from Sigma-Aldrich
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USP2 siRNA (Human) - CRH6012 from Cohesion Biosciences
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USP2 - MBS8233595 from MyBioSource
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shRNA set against Human USP2 (NM_171997.2) - SHH441340 from Creative biogene
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Human USP2 siRNA - orb266514 from Biorbyt
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USP2 shRNA Plasmid (Human) - CHH6012 from Cohesion Biosciences
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USP2 miRNA 3'UTR clone - MiUTR3H-07043 from Creative biogene
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USP2 miRNA 3'UTR clone - MiUTR3H-07044 from Creative biogene
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